1q67

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{{STRUCTURE_1q67| PDB=1q67 | SCENE= }}
{{STRUCTURE_1q67| PDB=1q67 | SCENE= }}
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'''Crystal structure of Dcp1p'''
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===Crystal structure of Dcp1p===
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==Overview==
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A major pathway of eukaryotic mRNA turnover begins with deadenylation, followed by decapping and 5'--&gt;3' exonucleolytic degradation. A critical step in this pathway is decapping, which is carried out by an enzyme composed of Dcp1p and Dcp2p. The crystal structure of Dcp1p shows that it markedly resembles the EVH1 family of protein domains. Comparison of the proline-rich sequence (PRS)-binding sites in this family of proteins with Dcp1p indicates that it belongs to a novel class of EVH1 domains. Mapping of the sequence conservation on the molecular surface of Dcp1p reveals two prominent sites. One of these is required for the function of the Dcp1p-Dcp2p complex, and the other, corresponding to the PRS-binding site of EVH1 domains, is probably a binding site for decapping regulatory proteins. Moreover, a conserved hydrophobic patch is shown to be critical for decapping.
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{{ABSTRACT_PUBMED_14758354}}
==About this Structure==
==About this Structure==
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[[Category: Song, H.]]
[[Category: Song, H.]]
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Revision as of 16:06, 28 July 2008

Image:1q67.png

Template:STRUCTURE 1q67

Crystal structure of Dcp1p

Template:ABSTRACT PUBMED 14758354

About this Structure

1Q67 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of Dcp1p and its functional implications in mRNA decapping., She M, Decker CJ, Sundramurthy K, Liu Y, Chen N, Parker R, Song H, Nat Struct Mol Biol. 2004 Mar;11(3):249-56. Epub 2004 Feb 1. PMID:14758354

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