1r2b

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{{STRUCTURE_1r2b| PDB=1r2b | SCENE= }}
{{STRUCTURE_1r2b| PDB=1r2b | SCENE= }}
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'''Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide'''
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===Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide===
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==Overview==
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BCL6 encodes a transcription factor that represses genes necessary for the terminal differentiation of lymphocytes within germinal centers, and the misregulated expression of this factor is strongly implicated in several types of B cell lymphoma. The homodimeric BTB domain of BCL6 (also known as the POZ domain) is required for the repression activity of the protein and interacts directly with the SMRT and N-CoR corepressors that are found within large multiprotein histone deacetylase-containing complexes. We have identified a 17 residue fragment from SMRT that binds to the BCL6 BTB domain, and determined the crystal structure of the complex to 2.2 A. Two SMRT fragments bind symmetrically to the BCL6 BTB homodimer and, in combination with biochemical and in vivo data, the structure provides insight into the basis of transcriptional repression by this critical B cell lymphoma protein.
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==Disease==
==Disease==
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[[Category: Hdac complex]]
[[Category: Hdac complex]]
[[Category: Transcriptional repression]]
[[Category: Transcriptional repression]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:59:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:07:43 2008''

Revision as of 16:07, 28 July 2008

Image:1r2b.png

Template:STRUCTURE 1r2b

Contents

Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide

Template:ABSTRACT PUBMED 14690607

Disease

Known disease associated with this structure: Lymphoma, B-cell OMIM:[109565]

About this Structure

1R2B is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain., Ahmad KF, Melnick A, Lax S, Bouchard D, Liu J, Kiang CL, Mayer S, Takahashi S, Licht JD, Prive GG, Mol Cell. 2003 Dec;12(6):1551-64. PMID:14690607

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