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2h94

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{{STRUCTURE_2h94| PDB=2h94 | SCENE= }}
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'''Crystal Structure and Mechanism of human Lysine-Specific Demethylase-1'''
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===Crystal Structure and Mechanism of human Lysine-Specific Demethylase-1===
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==Overview==
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The reversible methylation of specific lysine residues in histone tails is crucial in epigenetic gene regulation. LSD1, the first known lysine-specific demethylase, selectively removes monomethyl and dimethyl, but not trimethyl modifications of Lys4 or Lys9 of histone-3. Here, we present the crystal structure of LSD1 at 2.9-A resolution. LSD1 forms a highly asymmetric, closely packed domain structure from which a long helical 'tower' domain protrudes. The active site cavity is spacious enough to accommodate several residues of the histone tail substrate, but does not appear capable of recognizing the different methylation states of the substrate lysine. This supports the hypothesis that trimethylated lysine is chemically rather than sterically discriminated. We present a biochemical analysis of LSD1 mutants that identifies crucial residues in the active site cavity and shows the importance of the SWIRM and tower domains for catalysis.
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(as it appears on PubMed at http://www.pubmed.gov), where 16799558 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16799558}}
==About this Structure==
==About this Structure==
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[[Category: Histone demethylase]]
[[Category: Histone demethylase]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:10:26 2008''

Revision as of 16:10, 28 July 2008

Image:2h94.png

Template:STRUCTURE 2h94

Crystal Structure and Mechanism of human Lysine-Specific Demethylase-1

Template:ABSTRACT PUBMED 16799558

About this Structure

2H94 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure and mechanism of human lysine-specific demethylase-1., Stavropoulos P, Blobel G, Hoelz A, Nat Struct Mol Biol. 2006 Jul;13(7):626-32. Epub 2006 Jun 25. PMID:16799558

Page seeded by OCA on Mon Jul 28 19:10:26 2008

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