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2o1i

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{{STRUCTURE_2o1i| PDB=2o1i | SCENE= }}
{{STRUCTURE_2o1i| PDB=2o1i | SCENE= }}
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'''RH(BPY)2CHRYSI complexed to mismatched DNA'''
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===RH(BPY)2CHRYSI complexed to mismatched DNA===
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==Overview==
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We report the 1.1-A resolution crystal structure of a bulky rhodium complex bound to two different DNA sites, mismatched and matched in the oligonucleotide 5'-(dCGGAAATTCCCG)2-3'. At the AC mismatch site, the structure reveals ligand insertion from the minor groove with ejection of both mismatched bases and elucidates how destabilized mispairs in DNA may be recognized. This unique binding mode contrasts with major groove intercalation, observed at a matched site, where doubling of the base pair rise accommodates stacking of the intercalator. Mass spectral analysis reveals different photocleavage products associated with the two binding modes in the crystal, with only products characteristic of mismatch binding in solution. This structure, illustrating two clearly distinct binding modes for a molecule with DNA, provides a rationale for the interrogation and detection of mismatches.
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(as it appears on PubMed at http://www.pubmed.gov), where 17194756 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17194756}}
==About this Structure==
==About this Structure==
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[[Category: Dna recognition]]
[[Category: Dna recognition]]
[[Category: Metallointercalator]]
[[Category: Metallointercalator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:11:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:10:55 2008''

Revision as of 16:11, 28 July 2008

Image:2o1i.png

Template:STRUCTURE 2o1i

RH(BPY)2CHRYSI complexed to mismatched DNA

Template:ABSTRACT PUBMED 17194756

About this Structure

Full crystallographic information is available from OCA.

Reference

Insights into finding a mismatch through the structure of a mispaired DNA bound by a rhodium intercalator., Pierre VC, Kaiser JT, Barton JK, Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):429-34. Epub 2006 Dec 28. PMID:17194756

Page seeded by OCA on Mon Jul 28 19:10:55 2008

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