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1o77

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[[Image:1o77.gif|left|200px]]
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{{STRUCTURE_1o77| PDB=1o77 | SCENE= }}
{{STRUCTURE_1o77| PDB=1o77 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE C713S MUTANT OF THE TIR DOMAIN OF HUMAN TLR2'''
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===CRYSTAL STRUCTURE OF THE C713S MUTANT OF THE TIR DOMAIN OF HUMAN TLR2===
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==Overview==
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The Toll/interleukin-1 receptor (TIR) domains are conserved modules in the intracellular regions of the Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). The domains are crucial for the signal transduction by these receptors, through homotypic interactions among the receptor and the downstream adapter TIR domains. Previous studies showed that the BB loop in the structure of the TIR domain forms a prominent conserved feature on the surface and is important for receptor signaling. Here we report the crystal structure of the C713S mutant of the TIR domain of human TLR2. An extensively associated dimer is observed in the crystal structure and mutations of several residues in this dimer interface abolished the function of the receptor. Moreover, the structure shows that the BB loop can adopt different conformations, which are required for the formation of this dimer. This asymmetric dimer might represent the TLR2:TLRx heterodimer in the function of this receptor.
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The line below this paragraph, {{ABSTRACT_PUBMED_12437972}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12437972 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12437972}}
==About this Structure==
==About this Structure==
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[[Category: Signal]]
[[Category: Signal]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:28:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:13:58 2008''

Revision as of 16:14, 28 July 2008

Image:1o77.png

Template:STRUCTURE 1o77

CRYSTAL STRUCTURE OF THE C713S MUTANT OF THE TIR DOMAIN OF HUMAN TLR2

Template:ABSTRACT PUBMED 12437972

About this Structure

1O77 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2., Tao X, Xu Y, Zheng Y, Beg AA, Tong L, Biochem Biophys Res Commun. 2002 Nov 29;299(2):216-21. PMID:12437972

Page seeded by OCA on Mon Jul 28 19:13:58 2008

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