This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1nvt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1nvt.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1nvt.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1nvt| PDB=1nvt | SCENE= }}
{{STRUCTURE_1nvt| PDB=1nvt | SCENE= }}
-
'''Crystal structure of Shikimate Dehydrogenase (AROE or MJ1084) in complex with NADP+'''
+
===Crystal structure of Shikimate Dehydrogenase (AROE or MJ1084) in complex with NADP+===
-
==Overview==
+
<!--
-
The crystal structure of Methanococcus jannaschii shikimate 5-dehydrogenase (MjSDH) bound to the cofactor nicotinamide adenine dinucleotide phosphate (NADP) has been determined at 2.35 A resolution. Shikimate 5-dehydrogenase (SDH) is responsible for NADP-dependent catalysis of the fourth step in shikimate biosynthesis, which is essential for aromatic amino acid metabolism in bacteria, microbial eukaryotes, and plants. The structure of MjSDH is a compact alpha/beta sandwich with two distinct domains, responsible for binding substrate and the NADP cofactor, respectively. A phylogenetically conserved deep cleft on the protein surface corresponds to the enzyme active site. The structure reveals a topologically new domain fold within the N-terminal segment of the polypeptide chain, which binds substrate and supports dimerization. Insights gained from homology modeling and sequence/structure comparisons suggest that the SDHs represent a unique class of dehydrogenases. The structure provides a framework for further investigation to discover and develop novel inhibitors targeting this essential enzyme.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12906831}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12906831 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12906831}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Psi]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:02:27 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:14:28 2008''

Revision as of 16:14, 28 July 2008

Image:1nvt.png

Template:STRUCTURE 1nvt

Crystal structure of Shikimate Dehydrogenase (AROE or MJ1084) in complex with NADP+

Template:ABSTRACT PUBMED 12906831

About this Structure

1NVT is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Crystal structure of shikimate 5-dehydrogenase (SDH) bound to NADP: insights into function and evolution., Padyana AK, Burley SK, Structure. 2003 Aug;11(8):1005-13. PMID:12906831

Page seeded by OCA on Mon Jul 28 19:14:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nvt"
Personal tools