1q38

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[[Image:1q38.gif|left|200px]]
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{{Seed}}
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[[Image:1q38.png|left|200px]]
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{{STRUCTURE_1q38| PDB=1q38 | SCENE= }}
{{STRUCTURE_1q38| PDB=1q38 | SCENE= }}
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'''Anastellin'''
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===Anastellin===
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==Overview==
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Anastellin is a carboxy-terminal fragment of the first FN3 domain from human fibronectin. It is capable of polymerizing fibronectin in vitro, and it displays anti-tumor, anti-metastatic and anti-angiogenic properties in vivo. We have determined the structure of anastellin using nuclear magnetic resonance spectroscopy and identified residues critical for its activity. Anastellin exhibits dynamic fluctuations and conformational exchange in solution. Its overall topology is very similar to the corresponding region of full-length FN3 domains. However, its hydrophobic core becomes solvent-accessible and some of its beta-strands lose their protection against hydrogen bonding to beta-strands from other molecules. These features seem to be relevant for the fibronectin polymerization activity of anastellin and resemble the characteristics of amyloid fibril precursors. We suggest that this analogy is not random and may reflect similarities between fibronectin and amyloid fibril formation.
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The line below this paragraph, {{ABSTRACT_PUBMED_12946358}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12946358 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12946358}}
==About this Structure==
==About this Structure==
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1Q38 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q38 OCA].
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1Q38 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q38 OCA].
==Reference==
==Reference==
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[[Category: Dynamic fluctuation]]
[[Category: Dynamic fluctuation]]
[[Category: Extracellular matrix]]
[[Category: Extracellular matrix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:48:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:15:09 2008''

Revision as of 16:15, 28 July 2008

Image:1q38.png

Template:STRUCTURE 1q38

Anastellin

Template:ABSTRACT PUBMED 12946358

About this Structure

1Q38 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Anastellin, an FN3 fragment with fibronectin polymerization activity, resembles amyloid fibril precursors., Briknarova K, Akerman ME, Hoyt DW, Ruoslahti E, Ely KR, J Mol Biol. 2003 Sep 5;332(1):205-15. PMID:12946358

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