1sny

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{{Seed}}
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{{STRUCTURE_1sny| PDB=1sny | SCENE= }}
{{STRUCTURE_1sny| PDB=1sny | SCENE= }}
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'''Carbonyl reductase Sniffer of D. melanogaster'''
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===Carbonyl reductase Sniffer of D. melanogaster===
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==Overview==
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In vivo studies with the fruit-fly Drosophila melanogaster have shown that the Sniffer protein prevents age-dependent and oxidative stress-induced neurodegenerative processes. Sniffer is a NADPH-dependent carbonyl reductase belonging to the enzyme family of short-chain dehydrogenases/reductases (SDRs). The crystal structure of the homodimeric Sniffer protein from Drosophila melanogaster in complex with NADP+ has been determined by multiple-wavelength anomalous dispersion and refined to a resolution of 1.75 A. The observed fold represents a typical dinucleotide-binding domain as detected for other SDRs. With respect to the cofactor-binding site and the region referred to as substrate-binding loop, the Sniffer protein shows a striking similarity to the porcine carbonyl reductase (PTCR). This loop, in both Sniffer and PTCR, is substantially shortened compared to other SDRs. In most enzymes of the SDR family this loop adopts a well-defined conformation only after substrate binding and remains disordered in the absence of any bound ligands or even if only the dinucleotide cofactor is bound. In the structure of the Sniffer protein, however, the conformation of this loop is well defined, although no substrate is present. Molecular modeling studies provide an idea of how binding of substrate molecules to Sniffer could possibly occur.
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(as it appears on PubMed at http://www.pubmed.gov), where 15364585 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15364585}}
==About this Structure==
==About this Structure==
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[[Category: Dinucleotide binding motif]]
[[Category: Dinucleotide binding motif]]
[[Category: Rossmann fold]]
[[Category: Rossmann fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:56:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:16:44 2008''

Revision as of 16:16, 28 July 2008

Image:1sny.png

Template:STRUCTURE 1sny

Carbonyl reductase Sniffer of D. melanogaster

Template:ABSTRACT PUBMED 15364585

About this Structure

1SNY is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structural insights into the neuroprotective-acting carbonyl reductase Sniffer of Drosophila melanogaster., Sgraja T, Ulschmid J, Becker K, Schneuwly S, Klebe G, Reuter K, Heine A, J Mol Biol. 2004 Oct 1;342(5):1613-24. PMID:15364585

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