1p49

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{{STRUCTURE_1p49| PDB=1p49 | SCENE= }}
{{STRUCTURE_1p49| PDB=1p49 | SCENE= }}
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'''Structure of Human Placental Estrone/DHEA Sulfatase'''
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===Structure of Human Placental Estrone/DHEA Sulfatase===
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==Overview==
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Estrone sulfatase (ES; 562 amino acids), one of the key enzymes responsible for maintaining high levels of estrogens in breast tumor cells, is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES, purified from the microsomal fraction of human placentas, has been determined at 2.60-A resolution by x-ray crystallography. This structure shows a domain consisting of two antiparallel alpha-helices that protrude from the roughly spherical molecule, thereby giving the molecule a "mushroom-like" shape. These highly hydrophobic helices, each about 40 A long, are capable of traversing the membrane, thus presumably anchoring the functional domain on the membrane surface facing the ER lumen. The location of the transmembrane domain is such that the opening to the active site, buried deep in a cavity of the "gill" of the "mushroom," rests near the membrane surface, thereby suggesting a role of the lipid bilayer in catalysis. This simple architecture could be a prototype utilized by the ER membrane in dictating the form and the function of ER-resident enzymes.
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The line below this paragraph, {{ABSTRACT_PUBMED_12657638}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12657638 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12657638}}
==About this Structure==
==About this Structure==
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[[Category: Steroid biosynthesis]]
[[Category: Steroid biosynthesis]]
[[Category: Steroid sulfatase]]
[[Category: Steroid sulfatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:39:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:20:26 2008''

Revision as of 16:20, 28 July 2008

Image:1p49.png

Template:STRUCTURE 1p49

Structure of Human Placental Estrone/DHEA Sulfatase

Template:ABSTRACT PUBMED 12657638

About this Structure

1P49 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human estrone sulfatase suggests functional roles of membrane association., Hernandez-Guzman FG, Higashiyama T, Pangborn W, Osawa Y, Ghosh D, J Biol Chem. 2003 Jun 20;278(25):22989-97. Epub 2003 Mar 25. PMID:12657638

Page seeded by OCA on Mon Jul 28 19:20:26 2008

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