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2pqg

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{{STRUCTURE_2pqg| PDB=2pqg | SCENE= }}
{{STRUCTURE_2pqg| PDB=2pqg | SCENE= }}
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'''Crystal structure of inactive ribosome inactivating protein from maize (b-32)'''
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===Crystal structure of inactive ribosome inactivating protein from maize (b-32)===
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==Overview==
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Maize ribosome-inactivating protein is classified as a class III or an atypical RNA N-glycosidase. It is synthesized as an inactive precursor with a 25-amino acid internal inactivation region, which is removed in the active form. As the first structural example of this class of proteins, crystals of the precursor and the active form were diffracted to 2.4 and 2.5 A, respectively. The two proteins are similar, with main chain root mean square deviation (RMSD) of 0.519. In the precursor, the inactivation region is found on the protein surface and consists of a flexible loop followed by a long alpha-helix. This region diminished both the interaction with ribosome and cytotoxicity, but not cellular uptake. Like bacterial ribosome-inactivating proteins, maize ribosome-inactivating protein does not have a back-up glutamate in the active site, which helps the protein to retain some activity if the catalytic glutamate is mutated. The structure reveals that the active site is too small to accommodate two glutamate residues. Our structure suggests that maize ribosome-inactivating protein may represent an intermediate product in the evolution of ribosome-inactivating proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 17855394 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17855394}}
==About this Structure==
==About this Structure==
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[[Category: Pro-rip]]
[[Category: Pro-rip]]
[[Category: Ribosome inactivating protein]]
[[Category: Ribosome inactivating protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:37:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:20:47 2008''

Revision as of 16:20, 28 July 2008

Image:2pqg.png

Template:STRUCTURE 2pqg

Crystal structure of inactive ribosome inactivating protein from maize (b-32)

Template:ABSTRACT PUBMED 17855394

About this Structure

2PQG is a Single protein structure of sequence from Zea mays. Full crystallographic information is available from OCA.

Reference

Structure-function study of maize ribosome-inactivating protein: implications for the internal inactivation region and the sole glutamate in the active site., Mak AN, Wong YT, An YJ, Cha SS, Sze KH, Au SW, Wong KB, Shaw PC, Nucleic Acids Res. 2007;35(18):6259-67. Epub 2007 Sep 13. PMID:17855394

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