2qto

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2qto.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2qto.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2qto| PDB=2qto | SCENE= }}
{{STRUCTURE_2qto| PDB=2qto | SCENE= }}
-
'''An anisotropic model for potassium channel KcsA'''
+
===An anisotropic model for potassium channel KcsA===
-
==Overview==
+
<!--
-
We report a normal-mode method for anisotropic refinement of membrane-protein structures, based on a hypothesis that the global near-native-state disordering of membrane proteins in crystals follows low-frequency normal modes. Thus, a small set of modes is sufficient to represent the anisotropic thermal motions in X-ray crystallographic refinement. By applying the method to potassium channel KcsA at 3.2 A, we obtained a structural model with an improved fit with the diffraction data. Moreover, the improved electron density maps allowed for large structural adjustments for 12 residues in each subunit, including the rebuilding of 3 missing side chains. Overall, the anisotropic KcsA structure at 3.2 A was systematically closer to a 2.0 A KcsA structure, especially in the selectivity filter. Furthermore, the anisotropic thermal ellipsoids from the refinement revealed functionally relevant structural flexibility. We expect this method to be a valuable tool for structural refinement of many membrane proteins with moderate-resolution diffraction data.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17698000}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17698000 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17698000}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Normal-mode refinement]]
[[Category: Normal-mode refinement]]
[[Category: Potassium channel]]
[[Category: Potassium channel]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:39:34 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:20:53 2008''

Revision as of 16:20, 28 July 2008

Image:2qto.png

Template:STRUCTURE 2qto

An anisotropic model for potassium channel KcsA

Template:ABSTRACT PUBMED 17698000

About this Structure

2QTO is a Single protein structure of sequence from Streptomyces lividans. Full crystallographic information is available from OCA.

Reference

Normal-mode refinement of anisotropic thermal parameters for potassium channel KcsA at 3.2 A crystallographic resolution., Chen X, Poon BK, Dousis A, Wang Q, Ma J, Structure. 2007 Aug;15(8):955-62. PMID:17698000

Page seeded by OCA on Mon Jul 28 19:20:53 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2qto"
Personal tools