1rp0

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{{STRUCTURE_1rp0| PDB=1rp0 | SCENE= }}
{{STRUCTURE_1rp0| PDB=1rp0 | SCENE= }}
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'''Crystal Structure of Thi1 protein from Arabidopsis thaliana'''
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===Crystal Structure of Thi1 protein from Arabidopsis thaliana===
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==Overview==
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Thiamin pyrophosphate is an essential coenzyme in all organisms that depend on fermentation, respiration or photosynthesis to produce ATP. It is synthesized through two independent biosynthetic routes: one for the synthesis of 2-methyl-4-amino-5-hydroxymethylpyrimidine pyrophosphate (pyrimidine moiety) and another for the synthesis of 4-methyl-5-(beta-hydroxyethyl) thiazole phosphate (thiazole moiety). Herein, we will describe the three-dimensional structure of THI1 protein from Arabidopsis thaliana determined by single wavelength anomalous diffraction to 1.6A resolution. The protein was produced using heterologous expression in bacteria, unexpectedly bound to 2-carboxylate-4-methyl-5-beta-(ethyl adenosine 5-diphosphate) thiazole, a potential intermediate of the thiazole biosynthesis in Eukaryotes. THI1 has a topology similar to dinucleotide binding domains and although details concerning its function are unknown, this work provides new clues about the thiazole biosynthesis in Eukaryotes.
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(as it appears on PubMed at http://www.pubmed.gov), where 16912043 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16912043}}
==About this Structure==
==About this Structure==
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[[Category: Biosynthetic protein]]
[[Category: Biosynthetic protein]]
[[Category: Protein ligand complex]]
[[Category: Protein ligand complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 22:16:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:25:15 2008''

Revision as of 16:25, 28 July 2008

Image:1rp0.png

Template:STRUCTURE 1rp0

Crystal Structure of Thi1 protein from Arabidopsis thaliana

Template:ABSTRACT PUBMED 16912043

About this Structure

1RP0 is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

Structure of the thiazole biosynthetic enzyme THI1 from Arabidopsis thaliana., Godoi PH, Galhardo RS, Luche DD, Van Sluys MA, Menck CF, Oliva G, J Biol Chem. 2006 Oct 13;281(41):30957-66. Epub 2006 Aug 15. PMID:16912043

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