1ual

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ual.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1ual.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ual| PDB=1ual | SCENE= }}
{{STRUCTURE_1ual| PDB=1ual | SCENE= }}
-
'''Crystal structure of tRNA(m1G37)methyltransferase: Insight into tRNA recognition'''
+
===Crystal structure of tRNA(m1G37)methyltransferase: Insight into tRNA recognition===
-
==Overview==
+
<!--
-
tRNA(m(1)G37)methyltransferase (TrmD) catalyzes the transfer of a methyl group from S-adenosyl-L- methionine (AdoMet) to G(37) within a subset of bacterial tRNA species, which have a G residue at the 36th position. The modified guanosine is adjacent to and 3' of the anticodon and is essential for the maintenance of the correct reading frame during translation. Here we report four crystal structures of TrmD from Haemophilus influenzae, as binary complexes with either AdoMet or S-adenosyl-L-homocysteine (AdoHcy), as a ternary complex with AdoHcy and phosphate, and as an apo form. This first structure of TrmD indicates that it functions as a dimer. It also suggests the binding mode of G(36)G(37) in the active site of TrmD and the catalytic mechanism. The N-terminal domain has a trefoil knot, in which AdoMet or AdoHcy is bound in a novel, bent conformation. The C-terminal domain shows structural similarity to trp repressor. We propose a plausible model for the TrmD(2)-tRNA(2) complex, which provides insights into recognition of the general tRNA structure by TrmD.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12773376}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12773376 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12773376}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Trmd]]
[[Category: Trmd]]
[[Category: Trna modification]]
[[Category: Trna modification]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:58:14 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:25:51 2008''

Revision as of 16:25, 28 July 2008

Image:1ual.png

Template:STRUCTURE 1ual

Crystal structure of tRNA(m1G37)methyltransferase: Insight into tRNA recognition

Template:ABSTRACT PUBMED 12773376

About this Structure

1UAL is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.

Reference

Crystal structure of tRNA(m1G37)methyltransferase: insights into tRNA recognition., Ahn HJ, Kim HW, Yoon HJ, Lee BI, Suh SW, Yang JK, EMBO J. 2003 Jun 2;22(11):2593-603. PMID:12773376

Page seeded by OCA on Mon Jul 28 19:25:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ual"
Personal tools