1wpg

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[[Image:1wpg.jpg|left|200px]]
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{{STRUCTURE_1wpg| PDB=1wpg | SCENE= }}
{{STRUCTURE_1wpg| PDB=1wpg | SCENE= }}
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'''Crystal structure of the SR CA2+-ATPase with MGF4'''
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===Crystal structure of the SR CA2+-ATPase with MGF4===
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==Overview==
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P-type ion transporting ATPases are ATP-powered ion pumps that establish ion concentration gradients across biological membranes. Transfer of bound cations to the lumenal or extracellular side occurs while the ATPase is phosphorylated. Here we report at 2.3 A resolution the structure of the calcium-ATPase of skeletal muscle sarcoplasmic reticulum, a representative P-type ATPase that is crystallized in the absence of Ca2+ but in the presence of magnesium fluoride, a stable phosphate analogue. This and other crystal structures determined previously provide atomic models for all four principal states in the reaction cycle. These structures show that the three cytoplasmic domains rearrange to move six out of ten transmembrane helices, thereby changing the affinity of the Ca2+-binding sites and the gating of the ion pathway. Release of ADP triggers the opening of the lumenal gate and release of phosphate its closure, effected mainly through movement of the A-domain, the actuator of transmembrane gates.
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The line below this paragraph, {{ABSTRACT_PUBMED_15448704}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15448704 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15448704}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues., Toyoshima C, Nomura H, Tsuda T, Nature. 2004 Nov 18;432(7015):361-8. Epub 2004 Sep 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15448704 15448704]
Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues., Toyoshima C, Nomura H, Tsuda T, Nature. 2004 Nov 18;432(7015):361-8. Epub 2004 Sep 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15448704 15448704]
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Structural biology. Pumping ions., MacLennan DH, Green NM, Nature. 2000 Jun 8;405(6787):633-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10864310 10864310]
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Calcium callisthenics., Green NM, MacLennan DH, Nature. 2002 Aug 8;418(6898):598-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12167844 12167844]
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Crystal structure of the calcium pump with a bound ATP analogue., Toyoshima C, Mizutani T, Nature. 2004 Jul 29;430(6999):529-35. Epub 2004 Jun 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15229613 15229613]
[[Category: Calcium-transporting ATPase]]
[[Category: Calcium-transporting ATPase]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Membrane protein]]
[[Category: Membrane protein]]
[[Category: P-type atpase]]
[[Category: P-type atpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:58:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:26:28 2008''

Revision as of 16:26, 28 July 2008

Image:1wpg.png

Template:STRUCTURE 1wpg

Crystal structure of the SR CA2+-ATPase with MGF4

Template:ABSTRACT PUBMED 15448704

About this Structure

1WPG is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues., Toyoshima C, Nomura H, Tsuda T, Nature. 2004 Nov 18;432(7015):361-8. Epub 2004 Sep 26. PMID:15448704

Structural biology. Pumping ions., MacLennan DH, Green NM, Nature. 2000 Jun 8;405(6787):633-4. PMID:10864310

Calcium callisthenics., Green NM, MacLennan DH, Nature. 2002 Aug 8;418(6898):598-9. PMID:12167844

Crystal structure of the calcium pump with a bound ATP analogue., Toyoshima C, Mizutani T, Nature. 2004 Jul 29;430(6999):529-35. Epub 2004 Jun 30. PMID:15229613

Page seeded by OCA on Mon Jul 28 19:26:28 2008

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