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1t91

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[[Image:1t91.gif|left|200px]]
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{{STRUCTURE_1t91| PDB=1t91 | SCENE= }}
{{STRUCTURE_1t91| PDB=1t91 | SCENE= }}
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'''crystal structure of human small GTPase Rab7(GTP)'''
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===crystal structure of human small GTPase Rab7(GTP)===
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==Overview==
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Rab7 regulates vesicle traffic from early to late endosomes, and from late endosomes to lysosomes. The crystal structure of Rab7-GTP in complex with the Rab7 binding domain of RILP reveals that Rab7 interacts with RILP specifically via two distinct areas, with the first one involving the switch and interswitch regions and the second one consisting of RabSF1 and RabSF4. Disruption of these interactions by mutations abrogates late endosomal/lysosomal targeting of Rab7 and RILP. The Rab7 binding domain of RILP forms a coiled-coil homodimer with two symmetric surfaces to interact with two separate Rab7-GTP molecules, forming a dyad configuration of Rab7-RILP(2)-Rab7. Mutations that disrupt RILP dimerization also abolish its interactions with Rab7-GTP and late endosomal/lysosomal targeting, suggesting that the dimeric form of RILP is a functional unit. Structural comparison suggests that the combined use of RabSF1 and RabSF4 with the switch regions may be a general mode of action for most Rab proteins in regulating membrane trafficking.
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The line below this paragraph, {{ABSTRACT_PUBMED_15933719}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15933719 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15933719}}
==About this Structure==
==About this Structure==
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[[Category: Protein transport]]
[[Category: Protein transport]]
[[Category: Small gtpase]]
[[Category: Small gtpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:41:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:26:38 2008''

Revision as of 16:26, 28 July 2008

Image:1t91.png

Template:STRUCTURE 1t91

crystal structure of human small GTPase Rab7(GTP)

Template:ABSTRACT PUBMED 15933719

About this Structure

1T91 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for recruitment of RILP by small GTPase Rab7., Wu M, Wang T, Loh E, Hong W, Song H, EMBO J. 2005 Apr 20;24(8):1491-501. Epub 2005 Mar 31. PMID:15933719

Page seeded by OCA on Mon Jul 28 19:26:38 2008

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