1nm7

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{{STRUCTURE_1nm7| PDB=1nm7 | SCENE= }}
{{STRUCTURE_1nm7| PDB=1nm7 | SCENE= }}
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'''Solution structure of the ScPex13p SH3 domain'''
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===Solution structure of the ScPex13p SH3 domain===
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==Overview==
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Pex13p is an essential component of the peroxisomal protein import machinery and interacts via its C-terminal SH3 domain with the type II SH3-ligand Pex14p and the non-PXXP protein Pex5p. We report the solution structure of the SH3 domain of Pex13p from Saccharomyces cerevisiae and the identification of a novel-binding pocket, which binds a non-PXXP-peptide representing the binding site of Pex5p. Chemical shift assays revealed the binding sites for Pex5p and Pex14p ligand peptides to be distinct and spatially separated. Competition assays demonstrated that the two ligand peptides can bind simultaneously to the SH3 domain.
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{{ABSTRACT_PUBMED_12595255}}
==About this Structure==
==About this Structure==
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1NM7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NM7 OCA].
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1NM7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NM7 OCA].
==Reference==
==Reference==
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[[Category: Sh3 domain]]
[[Category: Sh3 domain]]
[[Category: Yeast]]
[[Category: Yeast]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:41:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:31:37 2008''

Revision as of 16:31, 28 July 2008

Image:1nm7.png

Template:STRUCTURE 1nm7

Solution structure of the ScPex13p SH3 domain

Template:ABSTRACT PUBMED 12595255

About this Structure

1NM7 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

The ScPex13p SH3 domain exposes two distinct binding sites for Pex5p and Pex14p., Pires JR, Hong X, Brockmann C, Volkmer-Engert R, Schneider-Mergener J, Oschkinat H, Erdmann R, J Mol Biol. 2003 Mar 7;326(5):1427-35. PMID:12595255

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