2i2q

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[[Image:2i2q.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2i2q| PDB=2i2q | SCENE= }}
{{STRUCTURE_2i2q| PDB=2i2q | SCENE= }}
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'''Fission Yeast cofilin'''
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===Fission Yeast cofilin===
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==Overview==
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ADF/cofilins are key regulators of actin dynamics during cellular motility, yet their precise role and mechanism of action are shrouded in ambiguity. Direct observation of actin filaments by evanescent wave microscopy showed that cofilins from fission yeast and human do not increase the rate that pointed ends of actin filaments shorten beyond the rate for ADP-actin subunits, but both cofilins inhibit elongation and subunit dissociation at barbed ends. Direct observation also showed that cofilins from fission yeast, Acanthamoeba, and human sever actin filaments optimally at low-cofilin binding densities well below their K(d)s, but not at high binding densities. High concentrations of cofilin nucleate actin assembly. Thus, the action of cofilins in cells will depend on the local concentration of active cofilins: low concentrations favor severing, whereas high concentrations favor nucleation. These results establish a clear paradigm for actin turnover by cofilin in cells.
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(as it appears on PubMed at http://www.pubmed.gov), where 17018289 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17018289}}
==About this Structure==
==About this Structure==
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[[Category: Pollard, T D.]]
[[Category: Pollard, T D.]]
[[Category: N-terminal serine]]
[[Category: N-terminal serine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:00:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:31:59 2008''

Revision as of 16:32, 28 July 2008

Image:2i2q.png

Template:STRUCTURE 2i2q

Fission Yeast cofilin

Template:ABSTRACT PUBMED 17018289

About this Structure

2I2Q is a Single protein structure of sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.

Reference

Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin., Andrianantoandro E, Pollard TD, Mol Cell. 2006 Oct 6;24(1):13-23. PMID:17018289

Page seeded by OCA on Mon Jul 28 19:31:59 2008

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