2oqp

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{{STRUCTURE_2oqp| PDB=2oqp | SCENE= }}
{{STRUCTURE_2oqp| PDB=2oqp | SCENE= }}
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'''Solution structure of human interleukin-21'''
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===Solution structure of human interleukin-21===
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==Overview==
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The high resolution three-dimensional structure of human interleukin (hIL)-21 has been resolved by heteronuclear NMR spectroscopy. Overall, the hIL-21 structure is dominated by a well defined central four-helical bundle, arranged in an up-up-down-down topology, as observed for other cytokines. A segment of the hIL-21 molecule that includes the third helical segment, helix C, is observed to exist in two distinct and interchangeable states. In one conformer, the helix C segment is presented in a regular, alpha-helical conformation, whereas in the other conformer, this segment is largely disordered. A structure-based sequence alignment of hIL-21 with receptor complexes of the related cytokines, interleukin-2 and -4, implied that this particular segment is involved in receptor binding. An hIL-21 analog was designed to stabilize the region around helix C through the introduction of a segment grafted from hIL-4. This novel hIL-21 analog was demonstrated to exhibit a 10-fold increase in potency in a cellular assay.
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(as it appears on PubMed at http://www.pubmed.gov), where 17565991 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17565991}}
==About this Structure==
==About this Structure==
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2OQP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OQP OCA].
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2OQP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OQP OCA].
==Reference==
==Reference==
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[[Category: Four helix bundle]]
[[Category: Four helix bundle]]
[[Category: Multiple conformer]]
[[Category: Multiple conformer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:28:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:32:21 2008''

Revision as of 16:32, 28 July 2008

Image:2oqp.png

Template:STRUCTURE 2oqp

Solution structure of human interleukin-21

Template:ABSTRACT PUBMED 17565991

About this Structure

2OQP is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogue., Bondensgaard K, Breinholt J, Madsen D, Omkvist DH, Kang L, Worsaae A, Becker P, Schiodt CB, Hjorth SA, J Biol Chem. 2007 Aug 10;282(32):23326-36. Epub 2007 Jun 12. PMID:17565991

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