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2hi2

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{{STRUCTURE_2hi2| PDB=2hi2 | SCENE= }}
{{STRUCTURE_2hi2| PDB=2hi2 | SCENE= }}
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'''Crystal structure of native Neisseria gonorrhoeae Type IV pilin at 2.3 Angstroms Resolution'''
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===Crystal structure of native Neisseria gonorrhoeae Type IV pilin at 2.3 Angstroms Resolution===
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==Overview==
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Type IV pili (T4P) are long, thin, flexible filaments on bacteria that undergo assembly-disassembly from inner membrane pilin subunits and exhibit astonishing multifunctionality. Neisseria gonorrhoeae (gonococcal or GC) T4P are prototypic virulence factors and immune targets for increasingly antibiotic-resistant human pathogens, yet detailed structures are unavailable for any T4P. Here, we determined a detailed experimental GC-T4P structure by quantitative fitting of a 2.3 A full-length pilin crystal structure into a 12.5 A resolution native GC-T4P reconstruction solved by cryo-electron microscopy (cryo-EM) and iterative helical real space reconstruction. Spiraling three-helix bundles form the filament core, anchor the globular heads, and provide strength and flexibility. Protruding hypervariable loops and posttranslational modifications in the globular head shield conserved functional residues in pronounced grooves, creating a surprisingly corrugated pilus surface. These results clarify T4P multifunctionality and assembly-disassembly while suggesting unified assembly mechanisms for T4P, archaeal flagella, and type II secretion system filaments.
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The line below this paragraph, {{ABSTRACT_PUBMED_16949362}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16949362 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16949362}}
==About this Structure==
==About this Structure==
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[[Category: Membrane protein]]
[[Category: Membrane protein]]
[[Category: Type iv pilin]]
[[Category: Type iv pilin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:19:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:32:48 2008''

Revision as of 16:32, 28 July 2008

Image:2hi2.png

Template:STRUCTURE 2hi2

Crystal structure of native Neisseria gonorrhoeae Type IV pilin at 2.3 Angstroms Resolution

Template:ABSTRACT PUBMED 16949362

About this Structure

2HI2 is a Single protein structure of sequence from Neisseria gonorrhoeae. Full crystallographic information is available from OCA.

Reference

Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions., Craig L, Volkmann N, Arvai AS, Pique ME, Yeager M, Egelman EH, Tainer JA, Mol Cell. 2006 Sep 1;23(5):651-62. PMID:16949362

Page seeded by OCA on Mon Jul 28 19:32:48 2008

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