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1z7h

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[[Image:1z7h.gif|left|200px]]
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{{Seed}}
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[[Image:1z7h.png|left|200px]]
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{{STRUCTURE_1z7h| PDB=1z7h | SCENE= }}
{{STRUCTURE_1z7h| PDB=1z7h | SCENE= }}
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'''2.3 Angstrom crystal structure of tetanus neurotoxin light chain'''
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===2.3 Angstrom crystal structure of tetanus neurotoxin light chain===
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==Overview==
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TeNT is the causative agent of the neuroparalytic disease tetanus. A key component of TeNT is its light chain, a Zn(2+) endopeptidase that targets SNAREs. Recent structural studies of closely related BoNT endopeptidases indicate that substrate-binding exosites remote from a conserved active site are the primary determinants of substrate specificity. Here we report the 2.3 A X-ray crystal structure of TeNT-LC, determined by combined molecular replacement and MAD phasing. As expected, the overall structure of TeNT-LC is similar to the other known CNT light chain structures, including a conserved thermolysin-like core inserted between structurally distinct amino- and carboxy-terminal regions. Differences between TeNT-LC and the other CNT light chains are mainly limited to surface features such as unique electrostatic potential profiles. An analysis of surface residue conservation reveals a pattern of relatively high variability matching the path of substrate binding around BoNT/A, possibly serving to accommodate the variations in different SNARE targets of the CNT group.
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The line below this paragraph, {{ABSTRACT_PUBMED_15895988}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15895988 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15895988}}
==About this Structure==
==About this Structure==
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[[Category: Tent]]
[[Category: Tent]]
[[Category: Tetanus]]
[[Category: Tetanus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:16:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:34:25 2008''

Revision as of 16:34, 28 July 2008

Image:1z7h.png

Template:STRUCTURE 1z7h

2.3 Angstrom crystal structure of tetanus neurotoxin light chain

Template:ABSTRACT PUBMED 15895988

About this Structure

1Z7H is a Single protein structure of sequence from Clostridium tetani. Full crystallographic information is available from OCA.

Reference

2.3 A crystal structure of tetanus neurotoxin light chain., Breidenbach MA, Brunger AT, Biochemistry. 2005 May 24;44(20):7450-7. PMID:15895988

Page seeded by OCA on Mon Jul 28 19:34:25 2008

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