2j5x

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{{STRUCTURE_2j5x| PDB=2j5x | SCENE= }}
{{STRUCTURE_2j5x| PDB=2j5x | SCENE= }}
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'''STRUCTURE OF THE SMALL G PROTEIN ARF6 IN COMPLEX WITH GTPGAMMAS'''
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===STRUCTURE OF THE SMALL G PROTEIN ARF6 IN COMPLEX WITH GTPGAMMAS===
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==Overview==
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The small GTP-binding protein Arf6 coordinates membrane traffic at the plasma membrane with aspects of cytoskeleton organization. This function does not overlap with that of other members of the ADP-ribosylation factor (Arf) family, although their switch regions, which are their major sites of interaction with regulators and effectors, have virtually identical sequences. Here we report the crystal structure of full-length, non-myristoylated human Arf6 bound to GTPgammaS. Unlike their GDP-bound forms, the active forms of Arf6 and Arf1 are very similar. Thus, the switch regions are discriminatory elements between Arf isoforms in their inactive but not in their active forms, a property that may generalize to other families of small G proteins. This suggests that GTP-bound Arfs may establish specific interactions outside the switch regions and/or be recognized in their cellular context rather than as isolated proteins. The structure also allows further insight into the lack of spontaneous GTPase activity of Arf proteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_11266366}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11266366 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11266366}}
==About this Structure==
==About this Structure==
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[[Category: Ra]]
[[Category: Ra]]
[[Category: Transport]]
[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:23:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:34:29 2008''

Revision as of 16:34, 28 July 2008

Image:2j5x.png

Template:STRUCTURE 2j5x

STRUCTURE OF THE SMALL G PROTEIN ARF6 IN COMPLEX WITH GTPGAMMAS

Template:ABSTRACT PUBMED 11266366

About this Structure

2J5X is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1hfv. Full crystallographic information is available from OCA.

Reference

The structural GDP/GTP cycle of human Arf6., Pasqualato S, Menetrey J, Franco M, Cherfils J, EMBO Rep. 2001 Mar;2(3):234-8. PMID:11266366

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