2bfi

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[[Image:2bfi.gif|left|200px]]
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{{Seed}}
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[[Image:2bfi.png|left|200px]]
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{{STRUCTURE_2bfi| PDB=2bfi | SCENE= }}
{{STRUCTURE_2bfi| PDB=2bfi | SCENE= }}
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'''MOLECULAR BASIS FOR AMYLOID FIBRIL FORMATION AND STABILITY'''
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===MOLECULAR BASIS FOR AMYLOID FIBRIL FORMATION AND STABILITY===
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==Overview==
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The molecular structure of the amyloid fibril has remained elusive because of the difficulty of growing well diffracting crystals. By using a sequence-designed polypeptide, we have produced crystals of an amyloid fiber. These crystals diffract to high resolution (1 A) by electron and x-ray diffraction, enabling us to determine a detailed structure for amyloid. The structure reveals that the polypeptides form fibrous crystals composed of antiparallel beta-sheets in a cross-beta arrangement, characteristic of all amyloid fibers, and allows us to determine the side-chain packing within an amyloid fiber. The antiparallel beta-sheets are zipped together by means of pi-bonding between adjacent phenylalanine rings and salt-bridges between charge pairs (glutamic acid-lysine), thus controlling and stabilizing the structure. These interactions are likely to be important in the formation and stability of other amyloid fibrils.
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(as it appears on PubMed at http://www.pubmed.gov), where 15630094 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15630094}}
==About this Structure==
==About this Structure==
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[[Category: Pi-pi bonding]]
[[Category: Pi-pi bonding]]
[[Category: X-ray diffraction]]
[[Category: X-ray diffraction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:13:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:36:23 2008''

Revision as of 16:36, 28 July 2008

Image:2bfi.png

Template:STRUCTURE 2bfi

MOLECULAR BASIS FOR AMYLOID FIBRIL FORMATION AND STABILITY

Template:ABSTRACT PUBMED 15630094

About this Structure

2BFI is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Molecular basis for amyloid fibril formation and stability., Makin OS, Atkins E, Sikorski P, Johansson J, Serpell LC, Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):315-20. Epub 2005 Jan 3. PMID:15630094

Page seeded by OCA on Mon Jul 28 19:36:23 2008

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