1xsk

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[[Image:1xsk.gif|left|200px]]
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{{Seed}}
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[[Image:1xsk.png|left|200px]]
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{{STRUCTURE_1xsk| PDB=1xsk | SCENE= }}
{{STRUCTURE_1xsk| PDB=1xsk | SCENE= }}
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'''Structure of a Family 31 alpha glycosidase glycosyl-enzyme intermediate'''
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===Structure of a Family 31 alpha glycosidase glycosyl-enzyme intermediate===
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==Overview==
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We have determined the first structure of a family 31 alpha-glycosidase, that of YicI from Escherichia coli, both free and trapped as a 5-fluoroxylopyranosyl-enzyme intermediate via reaction with 5-fluoro-alpha-D-xylopyranosyl fluoride. Our 2.2-A resolution structure shows an intimately associated hexamer with structural elements from several monomers converging at each of the six active sites. Our kinetic and mass spectrometry analyses verified several of the features observed in our structural data, including a covalent linkage from the carboxylate side chain of the identified nucleophile Asp(416) to C-1 of the sugar ring. Structure-based sequence comparison of YicI with the mammalian alpha-glucosidases lysosomal alpha-glucosidase and sucrase-isomaltase predicts a high level of structural similarity and provides a foundation for understanding the various mutations of these enzymes that elicit human disease.
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(as it appears on PubMed at http://www.pubmed.gov), where 15501829 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15501829}}
==About this Structure==
==About this Structure==
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[[Category: Strynadka, N C.]]
[[Category: Strynadka, N C.]]
[[Category: Withers, S G.]]
[[Category: Withers, S G.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:27:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:36:41 2008''

Revision as of 16:36, 28 July 2008

Image:1xsk.png

Template:STRUCTURE 1xsk

Structure of a Family 31 alpha glycosidase glycosyl-enzyme intermediate

Template:ABSTRACT PUBMED 15501829

About this Structure

1XSK is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Mechanistic and structural analysis of a family 31 alpha-glycosidase and its glycosyl-enzyme intermediate., Lovering AL, Lee SS, Kim YW, Withers SG, Strynadka NC, J Biol Chem. 2005 Jan 21;280(3):2105-15. Epub 2004 Oct 22. PMID:15501829

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