3bv3

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{{STRUCTURE_3bv3| PDB=3bv3 | SCENE= }}
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'''Morpholino pyrrolotriazine P38 Alpha Map Kinase inhibitor compound 2'''
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===Morpholino pyrrolotriazine P38 Alpha Map Kinase inhibitor compound 2===
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==Overview==
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A novel series of compounds based on the pyrrolo[2,1-f][1,2,4]triazine ring system have been identified as potent p38alpha MAP kinase inhibitors. The synthesis, structure-activity relationships (SAR), and in vivo activity of selected analogs from this class of inhibitors are reported. Additional studies based on X-ray co-crystallography have revealed that one of the potent inhibitors from this series binds to the DFG-out conformation of the p38alpha enzyme.
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{{ABSTRACT_PUBMED_18364256}}
==About this Structure==
==About this Structure==
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[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:39:21 2008''

Revision as of 16:39, 28 July 2008

Image:3bv3.png

Template:STRUCTURE 3bv3

Morpholino pyrrolotriazine P38 Alpha Map Kinase inhibitor compound 2

Template:ABSTRACT PUBMED 18364256

About this Structure

3BV3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38alpha MAP kinase inhibitors., Wrobleski ST, Lin S, Hynes J Jr, Wu H, Pitt S, Shen DR, Zhang R, Gillooly KM, Shuster DJ, McIntyre KW, Doweyko AM, Kish KF, Tredup JA, Duke GJ, Sack JS, McKinnon M, Dodd J, Barrish JC, Schieven GL, Leftheris K, Bioorg Med Chem Lett. 2008 Mar 4;. PMID:18364256

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