1nyp

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[[Image:1nyp.gif|left|200px]]
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{{STRUCTURE_1nyp| PDB=1nyp | SCENE= }}
{{STRUCTURE_1nyp| PDB=1nyp | SCENE= }}
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'''4th LIM domain of PINCH protein'''
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===4th LIM domain of PINCH protein===
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==Overview==
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PINCH is an adaptor protein found in focal adhesions, large cellular complexes that link extracellular matrix to the actin cytoskeleton. PINCH, which contains an array of five LIM domains, has been implicated as a platform for multiple protein-protein interactions that mediate integrin signaling within focal adhesions. We had previously characterized the LIM1 domain of PINCH, which functions in focal adhesions by binding specifically to integrin-linked kinase. Using NMR spectroscopy, we show here that the PINCH LIM4 domain, while maintaining the conserved LIM scaffold, recognizes the third SH3 domain of another adaptor protein, Nck2 (also called Nckbeta or Grb4), in a manner distinct from that of the LIM1 domain. Point mutation of LIM residues in the SH3-binding interface disrupted LIM-SH3 interaction and substantially impaired localization of PINCH to focal adhesions. These data provide novel structural insight into LIM domain-mediated protein-protein recognition and demonstrate that the PINCH-Nck2 interaction is an important component of the focal adhesion assembly during integrin signaling.
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The line below this paragraph, {{ABSTRACT_PUBMED_12794636}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12794636 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12794636}}
==About this Structure==
==About this Structure==
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1NYP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYP OCA].
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1NYP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYP OCA].
==Reference==
==Reference==
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[[Category: Lim domain]]
[[Category: Lim domain]]
[[Category: Protein recognition]]
[[Category: Protein recognition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:08:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:43:46 2008''

Revision as of 16:43, 28 July 2008

Image:1nyp.png

Template:STRUCTURE 1nyp

4th LIM domain of PINCH protein

Template:ABSTRACT PUBMED 12794636

About this Structure

1NYP is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling., Velyvis A, Vaynberg J, Yang Y, Vinogradova O, Zhang Y, Wu C, Qin J, Nat Struct Biol. 2003 Jul;10(7):558-64. PMID:12794636

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