1npo
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(New page: 200px<br /><applet load="1npo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1npo, resolution 3.0Å" /> '''BOVINE NEUROPHYSIN II...)
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Revision as of 20:20, 20 November 2007
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BOVINE NEUROPHYSIN II COMPLEX WITH OXYTOCIN
Overview
The first crystal structure of the pituitary hormone oxytocin complexed, with its carrier protein neurophysin has been determined and refined to, 3.0 A resolution. The hormone-binding site is located at the end of a, 3(10)-helix and involves residues from both domains of each monomer., Hormone residues Tyr 2, which is buried deep in the binding pocket, and, Cys 1 have been confirmed as the key residues involved in, neurophysin-hormone recognition. We have compared the bound oxytocin, observed in the neurophysin-oxytocin complex, the X-ray structures of, unbound oxytocin analogues and the NMR-derived structure for bound, oxytocin. We find that while our structure is in agreement with the, previous crystallographic findings, it differs from the NMR result with, regard to how Tyr 2 of the hormone is recognized by neurophysin.
About this Structure
1NPO is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the neurophysin-oxytocin complex., Rose JP, Wu CK, Hsiao CD, Breslow E, Wang BC, Nat Struct Biol. 1996 Feb;3(2):163-9. PMID:8564543
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