This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1xlz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1xlz.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1xlz.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1xlz| PDB=1xlz | SCENE= }}
{{STRUCTURE_1xlz| PDB=1xlz | SCENE= }}
-
'''Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Filaminast'''
+
===Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Filaminast===
-
==Overview==
+
<!--
-
Phosphodiesterases (PDEs) comprise a large family of enzymes that catalyze the hydrolysis of cAMP or cGMP and are implicated in various diseases. We describe the high-resolution crystal structures of the catalytic domains of PDE4B, PDE4D, and PDE5A with ten different inhibitors, including the drug candidates cilomilast and roflumilast, for respiratory diseases. These cocrystal structures reveal a common scheme of inhibitor binding to the PDEs: (i) a hydrophobic clamp formed by highly conserved hydrophobic residues that sandwich the inhibitor in the active site; (ii) hydrogen bonding to an invariant glutamine that controls the orientation of inhibitor binding. A scaffold can be readily identified for any given inhibitor based on the formation of these two types of conserved interactions. These structural insights will enable the design of isoform-selective inhibitors with improved binding affinity and should facilitate the discovery of more potent and selective PDE inhibitors for the treatment of a variety of diseases.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15576036}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15576036 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15576036}}
==About this Structure==
==About this Structure==
Line 41: Line 45:
[[Category: Filaminast]]
[[Category: Filaminast]]
[[Category: Pde4b]]
[[Category: Pde4b]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:11:55 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:48:14 2008''

Revision as of 16:48, 28 July 2008

Image:1xlz.png

Template:STRUCTURE 1xlz

Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Filaminast

Template:ABSTRACT PUBMED 15576036

About this Structure

1XLZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the activity of drugs that inhibit phosphodiesterases., Card GL, England BP, Suzuki Y, Fong D, Powell B, Lee B, Luu C, Tabrizizad M, Gillette S, Ibrahim PN, Artis DR, Bollag G, Milburn MV, Kim SH, Schlessinger J, Zhang KY, Structure. 2004 Dec;12(12):2233-47. PMID:15576036

Page seeded by OCA on Mon Jul 28 19:48:14 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xlz"
Personal tools