2hr9

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{{STRUCTURE_2hr9| PDB=2hr9 | SCENE= }}
{{STRUCTURE_2hr9| PDB=2hr9 | SCENE= }}
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'''Solution structure of human translationally controlled tumor protein'''
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===Solution structure of human translationally controlled tumor protein===
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==Overview==
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Human translationally controlled tumor protein (TCTP) is a growth-related, calcium-binding protein. We determined the solution structure and backbone dynamics of human TCTP, and identified the calcium-binding site of human TCTP using multi-dimensional NMR spectroscopy. The overall structure of human TCTP has a rather rigid well-folded core and a very flexible long loop connected by a short two-strand beta-sheet, which shows a conserved fold in the TCTP family. The C-terminal portions of loop L(alpha3beta8) and strand beta9 and the N-terminal region of strand beta8 may form a calcium-binding site in the human TCTP structure, which is largely conserved in the sequence alignment of TCTPs. The K(d) value for the calcium binding is 0.022-0.025 M indicating a very weak calcium-binding site.
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(as it appears on PubMed at http://www.pubmed.gov), where 17897616 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17897616}}
==About this Structure==
==About this Structure==
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2HR9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1y41 1y41]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HR9 OCA].
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2HR9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1y41 1y41]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HR9 OCA].
==Reference==
==Reference==
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[[Category: Metal binding protein]]
[[Category: Metal binding protein]]
[[Category: Tumor protein]]
[[Category: Tumor protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:37:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:49:47 2008''

Revision as of 16:49, 28 July 2008

Image:2hr9.png

Template:STRUCTURE 2hr9

Solution structure of human translationally controlled tumor protein

Template:ABSTRACT PUBMED 17897616

About this Structure

2HR9 is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1y41. Full experimental information is available from OCA.

Reference

Solution structure and mapping of a very weak calcium-binding site of human translationally controlled tumor protein by NMR., Feng Y, Liu D, Yao H, Wang J, Arch Biochem Biophys. 2007 Nov 1;467(1):48-57. Epub 2007 Aug 30. PMID:17897616

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