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1zrr

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{{STRUCTURE_1zrr| PDB=1zrr | SCENE= }}
{{STRUCTURE_1zrr| PDB=1zrr | SCENE= }}
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'''Residual Dipolar Coupling Refinement of Acireductone Dioxygenase from Klebsiella'''
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===Residual Dipolar Coupling Refinement of Acireductone Dioxygenase from Klebsiella===
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==Overview==
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Acireductone dioxygenase (ARD) from Klebsiella ATCC 8724 is a metalloenzyme that is capable of catalyzing different reactions with the same substrates (acireductone and O2) depending upon the metal bound in the active site. A model for the solution structure of the paramagnetic Ni2+-containing ARD has been refined using residual dipolar couplings (RDCs) measured in two media. Additional dihedral restraints based on chemical shift (TALOS) were included in the refinement, and backbone structure in the vicinity of the active site was modeled from a crystallographic structure of the mouse homolog of ARD. The incorporation of residual dipolar couplings into the structural refinement alters the relative orientations of several structural features significantly, and improves local secondary structure determination. Comparisons between the solution structures obtained with and without RDCs are made, and structural similarities and differences between mouse and bacterial enzymes are described. Finally, the biological significance of these differences is considered.
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The line below this paragraph, {{ABSTRACT_PUBMED_16518698}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16518698 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16518698}}
==About this Structure==
==About this Structure==
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1ZRR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_oxytoca Klebsiella oxytoca]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m4o 1m4o]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZRR OCA].
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1ZRR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_oxytoca Klebsiella oxytoca]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m4o 1m4o]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZRR OCA].
==Reference==
==Reference==
A refined model for the structure of acireductone dioxygenase from Klebsiella ATCC 8724 incorporating residual dipolar couplings., Pochapsky TC, Pochapsky SS, Ju T, Hoefler C, Liang J, J Biomol NMR. 2006 Feb;34(2):117-27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16518698 16518698]
A refined model for the structure of acireductone dioxygenase from Klebsiella ATCC 8724 incorporating residual dipolar couplings., Pochapsky TC, Pochapsky SS, Ju T, Hoefler C, Liang J, J Biomol NMR. 2006 Feb;34(2):117-27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16518698 16518698]
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Modeling and experiment yields the structure of acireductone dioxygenase from Klebsiella pneumoniae., Pochapsky TC, Pochapsky SS, Ju T, Mo H, Al-Mjeni F, Maroney MJ, Nat Struct Biol. 2002 Dec;9(12):966-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12402029 12402029]
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Mechanistic studies of two dioxygenases in the methionine salvage pathway of Klebsiella pneumoniae., Dai Y, Pochapsky TC, Abeles RH, Biochemistry. 2001 May 29;40(21):6379-87. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11371200 11371200]
[[Category: Klebsiella oxytoca]]
[[Category: Klebsiella oxytoca]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Methionine salvage]]
[[Category: Methionine salvage]]
[[Category: Nickel]]
[[Category: Nickel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:59:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:49:57 2008''

Revision as of 16:50, 28 July 2008

Image:1zrr.png

Template:STRUCTURE 1zrr

Residual Dipolar Coupling Refinement of Acireductone Dioxygenase from Klebsiella

Template:ABSTRACT PUBMED 16518698

About this Structure

1ZRR is a Single protein structure of sequence from Klebsiella oxytoca. This structure supersedes the now removed PDB entry 1m4o. Full experimental information is available from OCA.

Reference

A refined model for the structure of acireductone dioxygenase from Klebsiella ATCC 8724 incorporating residual dipolar couplings., Pochapsky TC, Pochapsky SS, Ju T, Hoefler C, Liang J, J Biomol NMR. 2006 Feb;34(2):117-27. PMID:16518698

Modeling and experiment yields the structure of acireductone dioxygenase from Klebsiella pneumoniae., Pochapsky TC, Pochapsky SS, Ju T, Mo H, Al-Mjeni F, Maroney MJ, Nat Struct Biol. 2002 Dec;9(12):966-72. PMID:12402029

Mechanistic studies of two dioxygenases in the methionine salvage pathway of Klebsiella pneumoniae., Dai Y, Pochapsky TC, Abeles RH, Biochemistry. 2001 May 29;40(21):6379-87. PMID:11371200

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