We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

3c2j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_3c2j", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
Line 1: Line 1:
-
[[Image:3c2j.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:3c2j.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3c2j| PDB=3c2j | SCENE= }}
{{STRUCTURE_3c2j| PDB=3c2j | SCENE= }}
-
'''Crystal structure analysis of trioxacarcin A covalently bound to d(AACCGGTT)'''
+
===Crystal structure analysis of trioxacarcin A covalently bound to d(AACCGGTT)===
-
==Overview==
+
<!--
-
We report a crystal structure that shows an antibiotic that extracts a nucleobase from a DNA molecule 'caught in the act' after forming a covalent bond but before departing with the base. The structure of trioxacarcin A covalently bound to double-stranded d(AACCGGTT) was determined to 1.78 A resolution by MAD phasing employing brominated oligonucleotides. The DNA-drug complex has a unique structure that combines alkylation (at the N7 position of a guanine), intercalation (on the 3'-side of the alkylated guanine), and base flip-out. An antibiotic-induced flipping-out of a single, nonterminal nucleobase from a DNA duplex was observed for the first time in a crystal structure.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18453630}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18453630 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18453630}}
==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Base flipping]]
[[Category: Base flipping]]
[[Category: Dna-drug complex]]
[[Category: Dna-drug complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 4 09:54:35 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:50:07 2008''

Revision as of 16:50, 28 July 2008

Image:3c2j.png

Template:STRUCTURE 3c2j

Crystal structure analysis of trioxacarcin A covalently bound to d(AACCGGTT)

Template:ABSTRACT PUBMED 18453630

About this Structure

3C2J is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Crystal structure of trioxacarcin A covalently bound to DNA., Pfoh R, Laatsch H, Sheldrick GM, Nucleic Acids Res. 2008 May 3;. PMID:18453630

Page seeded by OCA on Mon Jul 28 19:50:07 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3c2j"
Personal tools