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3c2j

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{{STRUCTURE_3c2j| PDB=3c2j | SCENE= }}
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'''Crystal structure analysis of trioxacarcin A covalently bound to d(AACCGGTT)'''
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===Crystal structure analysis of trioxacarcin A covalently bound to d(AACCGGTT)===
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==Overview==
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We report a crystal structure that shows an antibiotic that extracts a nucleobase from a DNA molecule 'caught in the act' after forming a covalent bond but before departing with the base. The structure of trioxacarcin A covalently bound to double-stranded d(AACCGGTT) was determined to 1.78 A resolution by MAD phasing employing brominated oligonucleotides. The DNA-drug complex has a unique structure that combines alkylation (at the N7 position of a guanine), intercalation (on the 3'-side of the alkylated guanine), and base flip-out. An antibiotic-induced flipping-out of a single, nonterminal nucleobase from a DNA duplex was observed for the first time in a crystal structure.
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(as it appears on PubMed at http://www.pubmed.gov), where 18453630 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18453630}}
==About this Structure==
==About this Structure==
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[[Category: Base flipping]]
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[[Category: Dna-drug complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 4 09:54:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:50:07 2008''

Revision as of 16:50, 28 July 2008

Image:3c2j.png

Template:STRUCTURE 3c2j

Crystal structure analysis of trioxacarcin A covalently bound to d(AACCGGTT)

Template:ABSTRACT PUBMED 18453630

About this Structure

3C2J is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Crystal structure of trioxacarcin A covalently bound to DNA., Pfoh R, Laatsch H, Sheldrick GM, Nucleic Acids Res. 2008 May 3;. PMID:18453630

Page seeded by OCA on Mon Jul 28 19:50:07 2008

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