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1nnp

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[[Image:1nnp.gif|left|200px]]
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{{STRUCTURE_1nnp| PDB=1nnp | SCENE= }}
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'''X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.9 A resolution. Crystallization without zinc ions.'''
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===X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.9 A resolution. Crystallization without zinc ions.===
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==Overview==
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Two X-ray structures of the GluR2 ligand-binding core in complex with (S)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid ((S)-ATPA) have been determined with and without Zn(2+) ions. (S)-ATPA induces a domain closure of ca. 21 degrees compared to the apo form. The tert-butyl moiety of (S)-ATPA is buried in a partially hydrophobic pocket and forces the ligand into the glutamate-like binding mode. The structures provide new insight into the molecular basis of agonist selectivity between AMPA and kainate receptors.
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(as it appears on PubMed at http://www.pubmed.gov), where 12593667 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12593667}}
==About this Structure==
==About this Structure==
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[[Category: Ionotropic glutamate receptor glur2]]
[[Category: Ionotropic glutamate receptor glur2]]
[[Category: Ligand-binding core]]
[[Category: Ligand-binding core]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:45:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:52:33 2008''

Revision as of 16:52, 28 July 2008

Image:1nnp.png

Template:STRUCTURE 1nnp

X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.9 A resolution. Crystallization without zinc ions.

Template:ABSTRACT PUBMED 12593667

About this Structure

1NNP is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity., Lunn ML, Hogner A, Stensbol TB, Gouaux E, Egebjerg J, Kastrup JS, J Med Chem. 2003 Feb 27;46(5):872-5. PMID:12593667

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