2ovy

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[[Image:2ovy.gif|left|200px]]
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{{STRUCTURE_2ovy| PDB=2ovy | SCENE= }}
{{STRUCTURE_2ovy| PDB=2ovy | SCENE= }}
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'''Crystal structure of the catalytic domain of rat phosphodiesterase 10A'''
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===Crystal structure of the catalytic domain of rat phosphodiesterase 10A===
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==Overview==
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A papaverine based pharmacophore model for PDE10A inhibition was generated via SBDD and used to design a library of 4-amino-6,7-dimethoxyquinazolines. From this library emerged an aryl ether pyrrolidyl 6,7-dimethoxyquinazoline series that became the focal point for additional modeling, X-ray, and synthetic efforts toward increasing PDE10A inhibitory potency and selectivity versus PDE3A/B. These efforts culminated in the discovery of 29, a potent and selective brain penetrable inhibitor of PDE10A.
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(as it appears on PubMed at http://www.pubmed.gov), where 17228859 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17228859}}
==About this Structure==
==About this Structure==
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[[Category: Phosphodiesterase 10a]]
[[Category: Phosphodiesterase 10a]]
[[Category: Zn-binding site]]
[[Category: Zn-binding site]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:46:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:01:31 2008''

Revision as of 17:01, 28 July 2008

Image:2ovy.png

Template:STRUCTURE 2ovy

Crystal structure of the catalytic domain of rat phosphodiesterase 10A

Template:ABSTRACT PUBMED 17228859

About this Structure

2OVY is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors., Chappie TA, Humphrey JM, Allen MP, Estep KG, Fox CB, Lebel LA, Liras S, Marr ES, Menniti FS, Pandit J, Schmidt CJ, Tu M, Williams RD, Yang FV, J Med Chem. 2007 Jan 25;50(2):182-5. PMID:17228859

Page seeded by OCA on Mon Jul 28 20:01:31 2008

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