1z47

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[[Image:1z47.gif|left|200px]]
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{{STRUCTURE_1z47| PDB=1z47 | SCENE= }}
{{STRUCTURE_1z47| PDB=1z47 | SCENE= }}
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'''Structure of the ATPase subunit CysA of the putative sulfate ATP-binding cassette (ABC) transporter from Alicyclobacillus acidocaldarius'''
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===Structure of the ATPase subunit CysA of the putative sulfate ATP-binding cassette (ABC) transporter from Alicyclobacillus acidocaldarius===
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==Overview==
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CysA, the ATPase subunit of a putative sulfate ATP-binding cassette transport system of the gram-positive thermoacidophilic bacterium Alicyclobacillus acidocaldarius, was structurally characterized at a resolution of 2.0 Angstroms in the absence of nucleotides. In line with previous findings on ABC-ATPases the structures of the two monomers (called CysA-1 and CysA-2) in the asymmetric unit differ substantially in the arrangement of their individual (sub)domains. CysA-2 was found as a physiological dimer composed of two crystallographically related monomers that are arranged in an open state. Interestingly, while the regulatory domain of CysA-2 packs against its opposing domain that of CysA-1 undergoes a conformational change and, in the dimer, would interfere with the opposing monomer thereby preventing solute translocation. Whether this conformational state is used for regulatory purposes will be discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 15893314 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15893314}}
==About this Structure==
==About this Structure==
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[[Category: Alpha/beta motif]]
[[Category: Alpha/beta motif]]
[[Category: Beta sandwich]]
[[Category: Beta sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:09:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:05:57 2008''

Revision as of 17:06, 28 July 2008

Image:1z47.png

Template:STRUCTURE 1z47

Structure of the ATPase subunit CysA of the putative sulfate ATP-binding cassette (ABC) transporter from Alicyclobacillus acidocaldarius

Template:ABSTRACT PUBMED 15893314

About this Structure

1Z47 is a Single protein structure of sequence from Alicyclobacillus acidocaldarius. Full crystallographic information is available from OCA.

Reference

Structure of the ATPase subunit CysA of the putative sulfate ATP-binding cassette (ABC) transporter from Alicyclobacillus acidocaldarius., Scheffel F, Demmer U, Warkentin E, Hulsmann A, Schneider E, Ermler U, FEBS Lett. 2005 May 23;579(13):2953-8. Epub 2005 Apr 25. PMID:15893314

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