2dx5

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{{STRUCTURE_2dx5| PDB=2dx5 | SCENE= }}
{{STRUCTURE_2dx5| PDB=2dx5 | SCENE= }}
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'''The complex structure between the mouse EAP45-GLUE domain and ubiquitin'''
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===The complex structure between the mouse EAP45-GLUE domain and ubiquitin===
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==Overview==
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ESCRT-II, a complex that sorts ubiquitinated membrane proteins to lysosomes, localizes to endosomes through interaction between the Vps36 subunit's GLUE domain and phosphatidylinositides (PIs). In yeast, a ubiquitin (Ub)-interacting NZF domain is inserted in Vps36 GLUE, whereas its mammalian counterpart, Eap45 GLUE, lacks the NZF domain. In the Eap45 GLUE-Ub complex structure, Ub binds far from the proposed PI-binding site of Eap45 GLUE, suggesting their independent binding.
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{{ABSTRACT_PUBMED_17057714}}
==About this Structure==
==About this Structure==
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[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
[[Category: Ubiquitin]]
[[Category: Ubiquitin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:33:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:08:21 2008''

Revision as of 17:08, 28 July 2008

Template:STRUCTURE 2dx5

The complex structure between the mouse EAP45-GLUE domain and ubiquitin

Template:ABSTRACT PUBMED 17057714

About this Structure

2DX5 is a Protein complex structure of sequences from Bos taurus and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of ubiquitin recognition by mammalian Eap45 GLUE domain., Hirano S, Suzuki N, Slagsvold T, Kawasaki M, Trambaiolo D, Kato R, Stenmark H, Wakatsuki S, Nat Struct Mol Biol. 2006 Nov;13(11):1031-2. Epub 2006 Oct 22. PMID:17057714

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