1osl

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[[Image:1osl.gif|left|200px]]
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{{STRUCTURE_1osl| PDB=1osl | SCENE= }}
{{STRUCTURE_1osl| PDB=1osl | SCENE= }}
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'''Solution structure of a dimeric lactose DNA-binding domain complexed to a nonspecific DNA sequence'''
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===Solution structure of a dimeric lactose DNA-binding domain complexed to a nonspecific DNA sequence===
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==Overview==
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Interaction of regulatory DNA binding proteins with their target sites is usually preceded by binding to nonspecific DNA. This speeds up the search for the target site by several orders of magnitude. We report the solution structure and dynamics of the complex of a dimeric lac repressor DNA binding domain with nonspecific DNA. The same set of residues can switch roles from a purely electrostatic interaction with the DNA backbone in the nonspecific complex to a highly specific binding mode with the base pairs of the cognate operator sequence. The protein-DNA interface of the nonspecific complex is flexible on biologically relevant time scales that may assist in the rapid and efficient finding of the target site.
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(as it appears on PubMed at http://www.pubmed.gov), where 15256668 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15256668}}
==About this Structure==
==About this Structure==
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1OSL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSL OCA].
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1OSL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSL OCA].
==Reference==
==Reference==
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[[Category: Nonspecific interaction]]
[[Category: Nonspecific interaction]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:14:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:10:02 2008''

Revision as of 17:10, 28 July 2008

Image:1osl.png

Template:STRUCTURE 1osl

Solution structure of a dimeric lactose DNA-binding domain complexed to a nonspecific DNA sequence

Template:ABSTRACT PUBMED 15256668

About this Structure

1OSL is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Structure and flexibility adaptation in nonspecific and specific protein-DNA complexes., Kalodimos CG, Biris N, Bonvin AM, Levandoski MM, Guennuegues M, Boelens R, Kaptein R, Science. 2004 Jul 16;305(5682):386-9. PMID:15256668

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