2aw2

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{{STRUCTURE_2aw2| PDB=2aw2 | SCENE= }}
{{STRUCTURE_2aw2| PDB=2aw2 | SCENE= }}
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'''Crystal structure of the human BTLA-HVEM complex'''
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===Crystal structure of the human BTLA-HVEM complex===
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==Overview==
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Five CD28-like proteins exert positive or negative effects on immune cells. Only four of these five receptors interact with members of the B7 family. The exception is BTLA (B and T lymphocyte attenuator), which instead interacts with the tumor necrosis factor receptor superfamily member HVEM (herpes virus entry mediator). To better understand this interaction, we determined the 2.8-A crystal structure of the BTLA-HVEM complex. This structure shows that BTLA binds the N-terminal cysteine-rich domain of HVEM and employs a unique binding surface compared with other CD28-like receptors. Moreover, the structure shows that BTLA recognizes the same surface on HVEM as gD (herpes virus glycoprotein D) and utilizes a similar binding motif. Light scattering analysis demonstrates that the extracellular domain of BTLA is monomeric and that BTLA and HVEM form a 1:1 complex. Alanine-scanning mutagenesis of HVEM was used to further define critical binding residues. Finally, BTLA adopts an immunoglobulin I-set fold. Despite structural similarities to other CD28-like members, BTLA represents a unique co-receptor.
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{{ABSTRACT_PUBMED_16169851}}
==About this Structure==
==About this Structure==
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[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
[[Category: Tnfrsf]]
[[Category: Tnfrsf]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:32:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:11:58 2008''

Revision as of 17:12, 28 July 2008

Image:2aw2.png

Template:STRUCTURE 2aw2

Crystal structure of the human BTLA-HVEM complex

Template:ABSTRACT PUBMED 16169851

About this Structure

2AW2 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex., Compaan DM, Gonzalez LC, Tom I, Loyet KM, Eaton D, Hymowitz SG, J Biol Chem. 2005 Nov 25;280(47):39553-61. Epub 2005 Sep 16. PMID:16169851

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