1ljx

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{{STRUCTURE_1ljx| PDB=1ljx | SCENE= }}
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'''THE STRUCTURE OF D(TPGPCPGPCPA)2 AT 293K: COMPARISON OF THE EFFECT OF SEQUENCE AND TEMPERATURE'''
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===THE STRUCTURE OF D(TPGPCPGPCPA)2 AT 293K: COMPARISON OF THE EFFECT OF SEQUENCE AND TEMPERATURE===
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==Overview==
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The crystal structure of a hexameric DNA fragment with the sequence d(TGCGCA)(2) has been solved and refined at 293 K at a resolution of 1.64 A. The molecule adopts a left-handed Z-type helical conformation which is common in alternating pyrimidine-purine sequences. The presence of A.T base pairs at the two terminals does not perturb the structure to any great degree. However, several sequence-specific microstructural changes are noticeable. The structure of the identical sequence determined at 120 K involving somewhat different crystallization conditions has been reported previously [Harper et al. (1998), Acta Cryst. D54, 1273-1284]. A comparison of the present structure with that at low temperature and with that of d(CGCGCG)(2) shows that the effect of the change in sequence is greater than the combined effect of changes in temperature and environment.
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(as it appears on PubMed at http://www.pubmed.gov), where 12136163 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12136163}}
==About this Structure==
==About this Structure==
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[[Category: Thiyagarajan, S.]]
[[Category: Thiyagarajan, S.]]
[[Category: Z-dna hexamer with at base pairs at the terminal]]
[[Category: Z-dna hexamer with at base pairs at the terminal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:59:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:12:56 2008''

Revision as of 17:12, 28 July 2008

Image:1ljx.png

Template:STRUCTURE 1ljx

THE STRUCTURE OF D(TPGPCPGPCPA)2 AT 293K: COMPARISON OF THE EFFECT OF SEQUENCE AND TEMPERATURE

Template:ABSTRACT PUBMED 12136163

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of d(TGCGCA)2 at 293 K: comparison of the effects of sequence and temperature., Thiyagarajan S, Satheesh Kumar P, Rajan SS, Gautham N, Acta Crystallogr D Biol Crystallogr. 2002 Aug;58(Pt 8):1381-4. Epub 2002, Jul 20. PMID:12136163

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