3bg1

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[[Image:3bg1.jpg|left|200px]]
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{{Seed}}
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[[Image:3bg1.png|left|200px]]
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{{STRUCTURE_3bg1| PDB=3bg1 | SCENE= }}
{{STRUCTURE_3bg1| PDB=3bg1 | SCENE= }}
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'''Architecture of a Coat for the Nuclear Pore Membrane'''
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===Architecture of a Coat for the Nuclear Pore Membrane===
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==Overview==
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The symmetric core of the nuclear pore complex can be considered schematically as a series of concentric cylinders. A peripheral cylinder coating the pore membrane contains the previously characterized, elongated heptamer that harbors Sec13-Nup145C in its middle section. Strikingly, Sec13-Nup145C crystallizes as a hetero-octamer in two space groups. Oligomerization of Sec13-Nup145C was confirmed biochemically. Importantly, the numerous interacting surfaces in the hetero-octamer are evolutionarily highly conserved, further underlining the physiological relevance of the oligomerization. The hetero-octamer forms a slightly curved, yet rigid rod of sufficient length to span the entire height of the proposed membrane-adjacent cylinder. In concordance with the dimensions and symmetry of the nuclear pore complex core, we suggest that the cylinder is constructed of four antiparallel rings, each ring being composed of eight heptamers arranged in a head-to-tail fashion. Our model proposes that the hetero-octamer would vertically traverse and connect the four stacked rings.
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The line below this paragraph, {{ABSTRACT_PUBMED_18160040}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18160040 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18160040}}
==About this Structure==
==About this Structure==
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[[Category: Transport]]
[[Category: Transport]]
[[Category: Wd repeat]]
[[Category: Wd repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:43:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:15:10 2008''

Revision as of 17:15, 28 July 2008

Image:3bg1.png

Template:STRUCTURE 3bg1

Architecture of a Coat for the Nuclear Pore Membrane

Template:ABSTRACT PUBMED 18160040

About this Structure

3BG1 is a Protein complex structure of sequences from Homo sapiens and Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Architecture of a coat for the nuclear pore membrane., Hsia KC, Stavropoulos P, Blobel G, Hoelz A, Cell. 2007 Dec 28;131(7):1313-26. PMID:18160040

Page seeded by OCA on Mon Jul 28 20:15:10 2008

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