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2f7k

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[[Image:2f7k.gif|left|200px]]
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{{STRUCTURE_2f7k| PDB=2f7k | SCENE= }}
{{STRUCTURE_2f7k| PDB=2f7k | SCENE= }}
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'''Crystal Structure of Human Pyridoxal Kinase'''
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===Crystal Structure of Human Pyridoxal Kinase===
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==Overview==
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Pyridoxal kinase, a member of the ribokinase superfamily, catalyzes the ATP-dependent phosphorylation reaction of vitamin B6 and is an essential enzyme in the formation of pyridoxal-5'-phosphate, a key cofactor for over 100 enzymes. Pyridoxal kinase is thus regarded as a potential target for pharmacological agents. In this paper, we report the 2.8 angstroms crystal structure of human pyridoxal kinase (HPLK) expressed in Escherichia coli. The diffraction data revealed unexpected merohedral perfect twinning along the crystallographic c axis. Taking perfect twinning into account, the structure in dimeric form was well refined according to the CNS program. Structure comparison reveals that the key 12-residue peptide over the active site in HPLK is a beta-strand/loop/beta-strand flap, while the corresponding peptide in sheep brain enzyme adopts a loop conformation. Moreover, HPLK possesses a more hydrophobic ATP-binding pocket. This structure will facilitate further biochemical studies and structure-based design of drugs related to pyridoxal kinase.
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The line below this paragraph, {{ABSTRACT_PUBMED_16600635}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16600635 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16600635}}
==About this Structure==
==About this Structure==
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[[Category: Tang, L.]]
[[Category: Tang, L.]]
[[Category: Alpha-beta structure]]
[[Category: Alpha-beta structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:33:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:15:52 2008''

Revision as of 17:15, 28 July 2008

Image:2f7k.png

Template:STRUCTURE 2f7k

Crystal Structure of Human Pyridoxal Kinase

Template:ABSTRACT PUBMED 16600635

About this Structure

2F7K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human pyridoxal kinase., Cao P, Gong Y, Tang L, Leung YC, Jiang T, J Struct Biol. 2006 Jun;154(3):327-32. Epub 2006 Mar 20. PMID:16600635

Page seeded by OCA on Mon Jul 28 20:15:52 2008

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