2rf4

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{{STRUCTURE_2rf4| PDB=2rf4 | SCENE= }}
{{STRUCTURE_2rf4| PDB=2rf4 | SCENE= }}
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'''Crystal structure of the RNA Polymerase I subcomplex A14/43'''
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===Crystal structure of the RNA Polymerase I subcomplex A14/43===
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==Overview==
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Synthesis of ribosomal RNA (rRNA) by RNA polymerase (Pol) I is the first step in ribosome biogenesis and a regulatory switch in eukaryotic cell growth. Here we report the 12 A cryo-electron microscopic structure for the complete 14-subunit yeast Pol I, a homology model for the core enzyme, and the crystal structure of the subcomplex A14/43. In the resulting hybrid structure of Pol I, A14/43, the clamp, and the dock domain contribute to a unique surface interacting with promoter-specific initiation factors. The Pol I-specific subunits A49 and A34.5 form a heterodimer near the enzyme funnel that acts as a built-in elongation factor and is related to the Pol II-associated factor TFIIF. In contrast to Pol II, Pol I has a strong intrinsic 3'-RNA cleavage activity, which requires the C-terminal domain of subunit A12.2 and, apparently, enables ribosomal RNA proofreading and 3'-end trimming.
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(as it appears on PubMed at http://www.pubmed.gov), where 18160037 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18160037}}
==About this Structure==
==About this Structure==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Transferase dna/rna]]
[[Category: Transferase dna/rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:47:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:18:28 2008''

Revision as of 17:18, 28 July 2008

Image:2rf4.png

Template:STRUCTURE 2rf4

Crystal structure of the RNA Polymerase I subcomplex A14/43

Template:ABSTRACT PUBMED 18160037

About this Structure

2RF4 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Functional architecture of RNA polymerase I., Kuhn CD, Geiger SR, Baumli S, Gartmann M, Gerber J, Jennebach S, Mielke T, Tschochner H, Beckmann R, Cramer P, Cell. 2007 Dec 28;131(7):1260-72. PMID:18160037

Page seeded by OCA on Mon Jul 28 20:18:28 2008

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