1ntn
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(New page: 200px<br /><applet load="1ntn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ntn, resolution 1.9Å" /> '''THE CRYSTAL STRUCTURE...)
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Revision as of 20:25, 20 November 2007
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THE CRYSTAL STRUCTURE OF NEUROTOXIN-I FROM NAJA NAJA OXIANA AT 1.9 ANGSTROMS RESOLUTION
Overview
Neurotoxin-1 from Naja naja oxiana venom (NTX-1) has been crystallized by, vapor diffusion in sitting drops. The crystals have cell dimensions of a =, 25.2 A, b = 75.6 A, c = 35.9 A, and are in space group P2(1)2(1)2(1)., Three-dimensional data to 1.9 A have been recorded by a Syntex P2(1), automatic diffractometer. The atomic structure of the toxin has been, determined by molecular replacement using the alpha-cobratoxin (alpha-CTX), as the search model. The position of 534 non-hydrogen protein atoms have, been determined. The model contains 65 water molecules. Refinement has led, to an R-factor of 19.3% at 1.9 A resolution. The secondary and tertiary, structures of NTX-1 have been analyzed and a comparison with structure of, the alpha-CTX has been made.
About this Structure
1NTN is a Single protein structure of sequence from Naja oxiana. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of neurotoxin-1 from Naja naja oxiana venom at 1.9 A resolution., Nickitenko AV, Michailov AM, Betzel C, Wilson KS, FEBS Lett. 1993 Apr 5;320(2):111-7. PMID:8458425
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