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1ntx

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(New page: 200px<br /><applet load="1ntx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ntx" /> '''SECONDARY STRUCTURE DETERMINATION FOR ALPHA-...)
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Revision as of 20:25, 20 November 2007

Image:1ntx.gif

SECONDARY STRUCTURE DETERMINATION FOR ALPHA-NEUROTOXIN FROM DENDROASPIS POLYLEPIS POLYLEPIS BASED ON SEQUENCE SPECIFIC PROTON NUCLEAR MAGNETIC RESONANCE ASSIGNMENTS

Overview

Sequence-specific assignments are presented for the polypeptide backbone, protons and a majority of the amino-acid-side-chain protons of, alpha-neurotoxin from Dendroaspis polylepis polylepis, and individual, amide proton-exchange rates with the solvent are reported. The secondary, structure and the hydrogen-bonding patterns in the regular secondary, structure elements are deduced from nuclear Overhauser effects and the, sequence locations of the slowly exchanging amide protons. The molecule, includes a three-stranded antiparallel beta-sheet, and there are, indications that two additional short chain segments are arranged in an, antiparallel beta-sheet. These structural elements are similar, but not, identical, to either the secondary structure reported for erabutoxin b in, single crystals, or the solution structure of cytotoxin CTXIIb from Naja, mossambica mossambica.

About this Structure

1NTX is a Single protein structure of sequence from Dendroaspis polylepis polylepis. Full crystallographic information is available from OCA.

Reference

Secondary structure determination for alpha-neurotoxin from Dendroaspis polylepis polylepis based on sequence-specific 1H-nuclear-magnetic-resonance assignments., Labhardt AM, Hunziker-Kwik EH, Wuthrich K, Eur J Biochem. 1988 Nov 1;177(2):295-305. PMID:2847926

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