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1qas

From Proteopedia

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[[Image:1qas.gif|left|200px]]
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{{Seed}}
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[[Image:1qas.png|left|200px]]
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{{STRUCTURE_1qas| PDB=1qas | SCENE= }}
{{STRUCTURE_1qas| PDB=1qas | SCENE= }}
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'''1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1'''
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===1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1===
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==Overview==
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The structure of the PH-domain truncated core of rat phosphoinositide-specific phospholipase C-delta 1 has been determined at 2.4 A resolution and compared to the structure previously determined in a different crystal form. The stereochemical relationship between the EF, catalytic, and C2 domains is essentially identical. The Ca2+ analogue Sm3+ binds at two sites between the jaws of the C2 domain. Sm3+ binding ejects three lysine residues which bridge the gap between the jaws and occupy the Ca2+ site in the apoenzyme, triggering a conformational change in the jaws. The distal sections of the C2 jaws move apart, opening the mouth by 9 A and creating a gap large enough to bind a phospholipid headgroup.
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(as it appears on PubMed at http://www.pubmed.gov), where 8784353 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8784353}}
==About this Structure==
==About this Structure==
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[[Category: Lipid degradation]]
[[Category: Lipid degradation]]
[[Category: Transducer]]
[[Category: Transducer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:04:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:24:38 2008''

Revision as of 17:24, 28 July 2008

Image:1qas.png

Template:STRUCTURE 1qas

1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1

Template:ABSTRACT PUBMED 8784353

About this Structure

1QAS is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

C2 domain conformational changes in phospholipase C-delta 1., Grobler JA, Essen LO, Williams RL, Hurley JH, Nat Struct Biol. 1996 Sep;3(9):788-95. PMID:8784353

Page seeded by OCA on Mon Jul 28 20:24:38 2008

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