2ot3

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[[Image:2ot3.gif|left|200px]]
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{{STRUCTURE_2ot3| PDB=2ot3 | SCENE= }}
{{STRUCTURE_2ot3| PDB=2ot3 | SCENE= }}
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'''Crystal structure of rabex-5 VPS9 domain in complex with nucleotide free RAB21'''
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===Crystal structure of rabex-5 VPS9 domain in complex with nucleotide free RAB21===
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==Overview==
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RABEX-5 and other exchange factors with VPS9 domains regulate endocytic trafficking through activation of the Rab family GTPases RAB5, RAB21 and RAB22. Here we report the crystal structure of the RABEX-5 catalytic core in complex with nucleotide-free RAB21, a key intermediate in the exchange reaction pathway. The structure reveals how VPS9 domain exchange factors recognize Rab GTPase substrates, accelerate GDP release and stabilize the nucleotide-free conformation. We further identify an autoinhibitory element in a predicted amphipathic helix located near the C terminus of the VPS9 domain. The autoinhibitory element overlaps with the binding site for the multivalent effector RABAPTIN-5 and potently suppresses the exchange activity of RABEX-5. Autoinhibition can be partially reversed by mutation of conserved residues on the nonpolar face of the predicted amphipathic helix or by assembly of the complex with RABAPTIN-5.
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(as it appears on PubMed at http://www.pubmed.gov), where 17450153 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17450153}}
==About this Structure==
==About this Structure==
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[[Category: Vesicular traffic]]
[[Category: Vesicular traffic]]
[[Category: Vps9 domain]]
[[Category: Vps9 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:36:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:26:23 2008''

Revision as of 17:26, 28 July 2008

Image:2ot3.png

Template:STRUCTURE 2ot3

Crystal structure of rabex-5 VPS9 domain in complex with nucleotide free RAB21

Template:ABSTRACT PUBMED 17450153

About this Structure

2OT3 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for Rab GTPase activation by VPS9 domain exchange factors., Delprato A, Lambright DG, Nat Struct Mol Biol. 2007 May;14(5):406-12. Epub 2007 Apr 22. PMID:17450153

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