1rl4

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[[Image:1rl4.jpg|left|200px]]
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{{STRUCTURE_1rl4| PDB=1rl4 | SCENE= }}
{{STRUCTURE_1rl4| PDB=1rl4 | SCENE= }}
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'''Plasmodium falciparum peptide deformylase complex with inhibitor'''
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===Plasmodium falciparum peptide deformylase complex with inhibitor===
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==Overview==
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An altered version of peptide deformylase from Plasmodium falciparum (PfPDF), the organism that causes the most devastating form of malaria, has been cocrystallized with a synthesized inhibitor that has submicromolar affinity for its target protein. The structure is solved at 2.2 A resolution, an improvement over the 2.8 A resolution achieved during the structural determination of unliganded PfPDF. This represents the successful outcome of modifying the protein construct in order to overcome adverse crystal contacts and other problems encountered in the study of unliganded PfPDF. Two molecules of PfPDF are found in the asymmetric unit of the current structure. The active site of each monomer of PfPDF is occupied by a proteolyzed fragment of the tripeptide-like inhibitor. Unexpectedly, each PfPDF subunit is associated with two nearly complete molecules of the inhibitor, found at a protein-protein interface. This is the first structure of a eukaryotic PDF protein, a potential drug target, in complex with a ligand.
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(as it appears on PubMed at http://www.pubmed.gov), where 15010544 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15010544}}
==About this Structure==
==About this Structure==
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[[Category: Peptide deformylase]]
[[Category: Peptide deformylase]]
[[Category: Plasmodium]]
[[Category: Plasmodium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:37:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:32:59 2008''

Revision as of 17:33, 28 July 2008

Image:1rl4.png

Template:STRUCTURE 1rl4

Plasmodium falciparum peptide deformylase complex with inhibitor

Template:ABSTRACT PUBMED 15010544

About this Structure

1RL4 is a Single protein structure of sequence from Plasmodium falciparum 3d7. Full crystallographic information is available from OCA.

Reference

An improved crystal form of Plasmodium falciparum peptide deformylase., Robien MA, Nguyen KT, Kumar A, Hirsh I, Turley S, Pei D, Hol WG, Protein Sci. 2004 Apr;13(4):1155-63. Epub 2004 Mar 9. PMID:15010544

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