2oxh

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{{Seed}}
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{{STRUCTURE_2oxh| PDB=2oxh | SCENE= }}
{{STRUCTURE_2oxh| PDB=2oxh | SCENE= }}
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'''The SOXYZ Complex of Paracoccus Pantotrophus'''
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===The SOXYZ Complex of Paracoccus Pantotrophus===
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==Overview==
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The bacterial Sox (sulfur oxidizing) system allows the utilization of inorganic sulfur compounds in energy metabolism. Central to this process is the SoxYZ complex that carries the pathway intermediates on a cysteine residue near the C terminus of SoxY. Crystal structures have been determined for Paracoccus pantotrophus SoxYZ with the carrier cysteine in the underivatized state, conjugated to the polysulfide mimic beta-mercaptoethanol, and as the sulfonate adduct pathway intermediate. The carrier cysteine is located on a peptide swinging arm and is bracketed on either side by diglycine dipeptides acting as molecular universal joints. This structure provides a novel solution to the requirement that the cysteine-bound intermediates be able to access and orient themselves within the active sites of multiple partner enzymes. Adjacent to the swinging arm there is a conserved, deep, apolar pocket into which the beta-mercaptoethanol adduct extends. This pocket would be well suited to a role in protecting labile pathway intermediates from adventitious reactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 17522046 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17522046}}
==About this Structure==
==About this Structure==
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[[Category: Sauve, V.]]
[[Category: Sauve, V.]]
[[Category: Immunoglobulin-like beta-sandwich fold]]
[[Category: Immunoglobulin-like beta-sandwich fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:52:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:33:48 2008''

Revision as of 17:33, 28 July 2008

Image:2oxh.png

Template:STRUCTURE 2oxh

The SOXYZ Complex of Paracoccus Pantotrophus

Template:ABSTRACT PUBMED 17522046

About this Structure

2OXH is a Protein complex structure of sequences from Paracoccus denitrificans. Full crystallographic information is available from OCA.

Reference

The SoxYZ complex carries sulfur cycle intermediates on a peptide swinging arm., Sauve V, Bruno S, Berks BC, Hemmings AM, J Biol Chem. 2007 Aug 10;282(32):23194-204. Epub 2007 May 23. PMID:17522046

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