1r44

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{{STRUCTURE_1r44| PDB=1r44 | SCENE= }}
{{STRUCTURE_1r44| PDB=1r44 | SCENE= }}
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'''Crystal Structure of VanX'''
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===Crystal Structure of VanX===
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==Overview==
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VanX is a zinc-dependent D-alanyl-D-alanine dipeptidase that is a critical component in a system that mediates transposon-based vancomycin resistance in enterococci. It is also a key drug target in circumventing clinical vancomycin resistance. The structure of VanX from E. faecium has been solved by X-ray crystallography and reveals a Zn(2+)-dipeptidase with a unique overall fold and a well-defined active site confined within a cavity of limited size. The crystal structures of VanX, the VanX:D-alanyl-D-alanine complex, the VanX:D-alanine complex, and VanX in complex with phosphonate and phosphinate transition-state analog inhibitors, are also presented at high resolution. Structural homology searches of known structures revealed that the fold of VanX is similar to those of two proteins: the N-terminal fragment of murine Sonic hedgehog and the Zn(2+)-dependent N-acyl-D-alanyl-D-alanine carboxypeptidase of S. albus G.
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(as it appears on PubMed at http://www.pubmed.gov), where 9702193 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9702193}}
==About this Structure==
==About this Structure==
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[[Category: E faecium]]
[[Category: E faecium]]
[[Category: Vanx]]
[[Category: Vanx]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:34:20 2008''

Revision as of 17:34, 28 July 2008

Image:1r44.png

Template:STRUCTURE 1r44

Crystal Structure of VanX

Template:ABSTRACT PUBMED 9702193

About this Structure

1R44 is a Single protein structure of sequence from Enterococcus faecium. Full crystallographic information is available from OCA.

Reference

The structure of VanX reveals a novel amino-dipeptidase involved in mediating transposon-based vancomycin resistance., Bussiere DE, Pratt SD, Katz L, Severin JM, Holzman T, Park CH, Mol Cell. 1998 Jul;2(1):75-84. PMID:9702193

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