1n99

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{{STRUCTURE_1n99| PDB=1n99 | SCENE= }}
{{STRUCTURE_1n99| PDB=1n99 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN'''
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===CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN===
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==Overview==
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Syntenin, a 33 kDa protein, interacts with several cell membrane receptors and with merlin, the product of the causal gene for neurofibromatosis type II. We report a crystal structure of the functional fragment of human syntenin containing two canonical PDZ domains, as well as binding studies for full-length syntenin, the PDZ tandem, and isolated PDZ domains. We show that the functional properties of syntenin are a result of independent interactions with target peptides, and that each domain is able to bind peptides belonging to two different classes: PDZ1 binds peptides from classes I and III, while PDZ2 interacts with classes I and II. The independent binding of merlin by PDZ1 and syndecan-4 by PDZ2 provides direct evidence for the coupling of syndecan-mediated signaling to actin regulation by merlin.
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{{ABSTRACT_PUBMED_12679023}}
==About this Structure==
==About this Structure==
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[[Category: Otlewski, J.]]
[[Category: Otlewski, J.]]
[[Category: Pdz domain]]
[[Category: Pdz domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:15:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:34:46 2008''

Revision as of 17:34, 28 July 2008

Image:1n99.png

Template:STRUCTURE 1n99

CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN

Template:ABSTRACT PUBMED 12679023

About this Structure

1N99 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

PDZ tandem of human syntenin: crystal structure and functional properties., Kang BS, Cooper DR, Jelen F, Devedjiev Y, Derewenda U, Dauter Z, Otlewski J, Derewenda ZS, Structure. 2003 Apr;11(4):459-68. PMID:12679023

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