1u58

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{{STRUCTURE_1u58| PDB=1u58 | SCENE= }}
{{STRUCTURE_1u58| PDB=1u58 | SCENE= }}
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'''Crystal structure of the murine cytomegalovirus MHC-I homolog m144'''
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===Crystal structure of the murine cytomegalovirus MHC-I homolog m144===
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==Overview==
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Large DNA viruses of the herpesvirus family produce proteins that mimic host MHC-I molecules as part of their immunoevasive strategy. The m144 glycoprotein, expressed by murine cytomegalovirus, is thought to be an MHC-I homolog whose expression prolongs viral survival in vivo by preventing natural killer cell activation. To explore the structural basis of this m144 function, we have determined the three-dimensional structure of an m144/beta2-microglobulin (beta2m) complex at 1.9A resolution. This structure reveals the canonical features of MHC-I molecules including readily identifiable alpha1, alpha2, and alpha3 domains. A unique disulfide bond links the alpha1 helix to the beta-sheet floor, explaining the known thermal stability of m144. Close juxtaposition of the alpha1 and alpha2 helices and the lack of critical residues that normally contribute to anchoring the peptide N and C termini eliminates peptide binding. A region of 13 amino acid residues, corresponding to the amino-terminal portion of the alpha2 helix, is missing in the electron density map, suggesting an area of structural flexibility that may be involved in ligand binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 16500675 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16500675}}
==About this Structure==
==About this Structure==
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[[Category: Mcmv]]
[[Category: Mcmv]]
[[Category: Mhc-i homolog]]
[[Category: Mhc-i homolog]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:46:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:43:15 2008''

Revision as of 17:43, 28 July 2008

Image:1u58.png

Template:STRUCTURE 1u58

Crystal structure of the murine cytomegalovirus MHC-I homolog m144

Template:ABSTRACT PUBMED 16500675

About this Structure

1U58 is a Single protein structure of sequence from Murid herpesvirus 1 and Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the murine cytomegalovirus MHC-I homolog m144., Natarajan K, Hicks A, Mans J, Robinson H, Guan R, Mariuzza RA, Margulies DH, J Mol Biol. 2006 Apr 21;358(1):157-71. Epub 2006 Feb 9. PMID:16500675

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