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1orp

From Proteopedia

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[[Image:1orp.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1orp| PDB=1orp | SCENE= }}
{{STRUCTURE_1orp| PDB=1orp | SCENE= }}
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'''Structure of a Trapped Endonuclease III-DNA Covalent Intermediate: Estranged-Adenine Complex'''
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===Structure of a Trapped Endonuclease III-DNA Covalent Intermediate: Estranged-Adenine Complex===
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==Overview==
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Nearly all cells express proteins that confer resistance to the mutagenic effects of oxidative DNA damage. The primary defense against the toxicity of oxidative nucleobase lesions in DNA is the base-excision repair (BER) pathway. Endonuclease III (EndoIII) is a [4Fe-4S] cluster-containing DNA glycosylase with repair activity specific for oxidized pyrimidine lesions in duplex DNA. We have determined the crystal structure of a trapped intermediate that represents EndoIII frozen in the act of repairing DNA. The structure of the protein-DNA complex provides insight into the ability of EndoIII to recognize and repair a diverse array of oxidatively damaged bases. This structure also suggests a rationale for the frequent occurrence in certain human cancers of a specific mutation in the related DNA repair protein MYH.
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(as it appears on PubMed at http://www.pubmed.gov), where 12840008 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12840008}}
==About this Structure==
==About this Structure==
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[[Category: Dna repair]]
[[Category: Dna repair]]
[[Category: Iron-sulfur cluster]]
[[Category: Iron-sulfur cluster]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:12:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:43:51 2008''

Revision as of 17:43, 28 July 2008

Image:1orp.png

Template:STRUCTURE 1orp

Structure of a Trapped Endonuclease III-DNA Covalent Intermediate: Estranged-Adenine Complex

Template:ABSTRACT PUBMED 12840008

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of a trapped endonuclease III-DNA covalent intermediate., Fromme JC, Verdine GL, EMBO J. 2003 Jul 1;22(13):3461-71. PMID:12840008

Page seeded by OCA on Mon Jul 28 20:43:51 2008

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